Early clinical outcomes demonstrate preserved cognitive function in children with average-risk medulloblastoma when treated with hyperfractionated radiation therapy

International Journal of Radiation Oncology, Biology, Physics
Tejpal GuptaRajiv Sarin

Abstract

To report on acute toxicity, longitudinal cognitive function, and early clinical outcomes in children with average-risk medulloblastoma. Twenty children ≥ 5 years of age classified as having average-risk medulloblastoma were accrued on a prospective protocol of hyperfractionated radiation therapy (HFRT) alone. Radiotherapy was delivered with two daily fractions (1 Gy/fraction, 6 to 8 hours apart, 5 days/week), initially to the neuraxis (36 Gy/36 fractions), followed by conformal tumor bed boost (32 Gy/32 fractions) for a total tumor bed dose of 68 Gy/68 fractions over 6 to 7 weeks. Cognitive function was prospectively assessed longitudinally (pretreatment and at specified posttreatment follow-up visits) with the Wechsler Intelligence Scale for Children to give verbal quotient, performance quotient, and full-scale intelligence quotient (FSIQ). The median age of the study cohort was 8 years (range, 5-14 years), representing a slightly older cohort. Acute hematologic toxicity was mild and self-limiting. Eight (40%) children had subnormal intelligence (FSIQ <85), including 3 (15%) with mild mental retardation (FSIQ 56-70) even before radiotherapy. Cognitive functioning for all tested domains was preserved in children evaluable at 3...Continue Reading

References

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Citations

Jul 22, 2015·International Journal of Radiation Oncology, Biology, Physics·Hugo Câmara-CostaUNKNOWN Quality of Survival Working Group of the Brain Tumour Group of SIOP-Europe
Nov 19, 2013·International Journal of Radiation Oncology, Biology, Physics·Colin KennedyUNKNOWN PNET4 study group of the Brain Tumour Group of The European branch of the International Society of Paediatric Oncology (SIOP
Apr 22, 2016·Pediatric Blood & Cancer·Andrea TangStacey Marjerrison
Sep 9, 2016·South Asian Journal of Cancer·Archya DasguptaRakesh Jalali
Jun 6, 2015·Journal of Child Neurology·Erika Roddy, Sabine Mueller
Apr 11, 2018·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Cailei ZhaoJianxiang Liao
Sep 4, 2015·Journal of Pediatric Hematology/oncology·Rolina K Al-WassiaCamelia Constantinescu
Jul 11, 2020·Pediatric Blood & Cancer·Ramandeep Singh AroraMaya Prasad
Sep 22, 2020·Brain Communications·Pierre-Aurélien BeuriatMichel Desmurget
Jun 1, 2017·Neuro-oncology Practice·Mathilde ChevignardGeorges Dellatolas

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