Early co-expression of cyclooxygenase-2 and renin in the rat kidney cortex contributes to the development of N(G)-nitro-L-arginine methyl ester induced hypertension

Canadian Journal of Physiology and Pharmacology
Elizabeth Alejandrina Guzmán-HernándezMaximiliano Ibarra-Barajas

Abstract

We investigated the involvement of cyclooxygenase-2 (COX-2) and the renin-angiotensin system in N(G)-nitro-L-arginine methyl ester (L-NAME)-induced hypertension. Male Wistar rats were treated with L-NAME (75.0 mg·(kg body mass)(-1)·day(-1), in their drinking water) for different durations (1-33 days). COX-2 and renin mRNA were measured using real-time PCR in the renal cortex, and prostanoids were assessed in the renal perfusate, whereas angiotensin II (Ang II) and Ang (1-7) were quantified in plasma. In some rats, nitric oxide synthase inhibition was carried out in conjunction with oral administration of captopril (30.0 mg·kg(-1)·day(-1)) or celecoxib (1.0 mg·kg(-1)·day(-1)) for 2 or 19 days. We found a parallel increase in renocortical COX-2 and renin mRNA starting at day 2 of treatment with L-NAME, and both peaked at 19-25 days. In addition, L-NAME increased renal 6-Keto-PGF(1α) (prostacyclin (PGI2) metabolite) and plasma Ang II from day 2, but reduced plasma Ang (1-7) at day 19. Captopril prevented the increase in blood pressure, which was associated with lower plasma Ang II and increased COX-2-derived 6-Keto-PGF(1α) at day 2 and plasma Ang (1-7) at day 19. Celecoxib partially prevented the increase in blood pressure; this e...Continue Reading

References

Oct 1, 1992·Kidney International·P MundelW Kriz
Jun 7, 1995·Molecular and Cellular Biochemistry·W LinzB A Schölkens
Dec 1, 1994·The Journal of Clinical Investigation·R C HarrisM D Breyer
Jul 1, 1996·Pflügers Archiv : European journal of physiology·K SchrickerA Kurtz
Apr 9, 1999·The Journal of Clinical Investigation·H F ChengR C Harris
Jan 3, 2001·American Journal of Physiology. Renal Physiology·B MannA Kurtz
Aug 18, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·G E CaugheyM J James
Jan 25, 2002·Annals of the New York Academy of Sciences·R J GryglewskiJ Madej
Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
May 16, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Martin C KammerlBernhard K Krämer
Jun 13, 2002·American Journal of Physiology. Renal Physiology·William H Beierwaltes
Jul 3, 2002·The Journal of Clinical Investigation·Zhonghua QiMatthew D Breyer
Aug 15, 2002·European Journal of Pharmacology·Vito De Gennaro ColonnaEugenio Muller
Nov 1, 2003·Thrombosis Research·Richard J GryglewskiEwa Marcinkiewicz
Apr 13, 2004·American Journal of Physiology. Renal Physiology·Hayo CastropJurgen Schnermann
Jun 12, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Carine M BoustanyLisa A Cassis
Jan 1, 2005·Prostaglandins, Leukotrienes, and Essential Fatty Acids·R J GryglewskiJ Swies
Oct 18, 2006·Proceedings of the National Academy of Sciences of the United States of America·Ming-Zhi ZhangRaymond C Harris
Feb 13, 2007·Current Opinion in Nephrology and Hypertension·Robson A S Santos, Anderson J Ferreira
Jun 21, 2011·Current Protocols in Mouse Biology·Xin ZhaoStephen F Vatner
Sep 29, 2011·Peptides·Aurelie Nguyen Dinh Cat, Rhian M Touyz

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Citations

Jun 7, 2019·The Journal of Toxicological Sciences·Zaher A Radi, K Nasir Khan
Sep 13, 2017·Journal of Biomedical Science·Miroslava MajzúnováIma Dovinová
May 6, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Michaela KosutovaMartina Cebova

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