Early coagulation disorders after severe burn injury: impact on mortality

Intensive Care Medicine
Athina LavrentievaMaria-Amalia Giala

Abstract

To evaluate the time course of coagulation markers in the early postburn period and clarify the role of coagulation alterations in organ failure and in mortality prognosis. This prospective study was conducted in the burn ICU of a tertiary hospital. 45 patients with severe thermal burn injury. Clinical data and coagulation and fibrinolysis parameters were measured during the first postburn week. The ICU 28-day mortality rate was 33%. Significant differences in the time course of coagulation markers were observed between survivors and nonsurvivors. SOFA score distinguished between patients with overt and nonovert disseminated intravascular coagulation (DIC) during the overall investigation period. Presence of overt DIC was related to mortality (OR=0.1). Antithrombin, protein S, plasminogen activator inhibitor 1, and SOFA score on day 3, protein C on day 5, and thrombin/antithrombin complexes on day 7 revealed a good prognostic value for ICU mortality, according to the area under ROC curves. Severe thermal injury is associated with the early activation of coagulation cascade, presence of DIC, organ failure, and increased mortality.

Associated Clinical Trials

References

Aug 1, 1989·Critical Care Medicine·J F HesselvikR Maller
Mar 1, 1982·Burns, Including Thermal Injury·J Gabilondo
Feb 7, 2001·The Journal of Burn Care & Rehabilitation·A Kowal-VernR L Gamelli
May 15, 2001·American Journal of Physiology. Lung Cellular and Molecular Physiology·K SoejimaD L Traber
Aug 30, 2001·Burns : Journal of the International Society for Burn Injuries·K AokiA Takada
Mar 19, 2005·Burns : Journal of the International Society for Burn Injuries·Juan P Barret, Pablo A Gomez
Jun 17, 2005·Intensive Care Medicine·Mirka SivulaVille Pettilä
Jul 5, 2005·Critical Care Clinics·Marcel Levi
Mar 8, 2006·Critical Care Medicine·Satoshi GandoUNKNOWN Japanese Association for Acute Medicine Disseminated Intravascular Coagulation (JAAM DIC) Study Group

❮ Previous
Next ❯

Citations

Jul 25, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Gerlinda E HermannRichard C Rogers
Jan 1, 2011·The Onderstepoort Journal of Veterinary Research·Etheresia PretoriusWendy J Van der Spuy
Jun 14, 2013·International Journal of Inflammation·Jayme A FarinaRodrigo G Rosique
Mar 19, 2013·Burns : Journal of the International Society for Burn Injuries·P B SherrenB Emerson
Jan 15, 2013·Burns : Journal of the International Society for Burn Injuries·Athina Lavrentieva
Sep 15, 2012·Resuscitation·Joonghee KimKyeong Won Kang
Nov 25, 2011·Burns : Journal of the International Society for Burn Injuries·Eva SchadenSibylle Kozek-Langenecker
Nov 29, 2011·Burns : Journal of the International Society for Burn Injuries·Laure Fayolle-PivotBernard Allaouchiche
Aug 6, 2011·Burns : Journal of the International Society for Burn Injuries·Lian Yee YipHong Ngee Chan
Oct 11, 2013·Critical Care Medicine·Sebastian RehbergPerenlei Enkhbaatar
Feb 16, 2015·Burns : Journal of the International Society for Burn Injuries·Athina Lavrentieva
Feb 9, 2016·Journal of Thrombosis and Haemostasis : JTH·G J GlasM J Schultz
Jun 9, 2016·Burns : Journal of the International Society for Burn Injuries·Grigory Levin, Ekaterina Sukhareva
Sep 8, 2016·Critical Care Clinics·Lisa RaeNicole Gibran
Oct 7, 2016·Thrombosis Journal·Hidesaku AsakuraUNKNOWN DIC subcommittee of the Japanese Society on Thrombosis and Hemostasis
Oct 4, 2016·Burns : Journal of the International Society for Burn Injuries·Charles E WadeTodd Huzar
May 16, 2017·Journal of Nippon Medical School = Nippon Ika Daigaku Zasshi·Hiroyuki KoamiSatoshi Inoue
Sep 23, 2010·Journal of Burn Care & Research : Official Publication of the American Burn Association·Manuel F StruckMichael Steen
Feb 9, 2016·World Journal of Critical Care Medicine·Areta Kowal-Vern, Bruce A Orkin
Jan 25, 2019·Current Opinion in Anaesthesiology·Tina L Palmieri
May 23, 2013·The Journal of Trauma and Acute Care Surgery·Rommel P LuNigel S Key
Mar 1, 2019·Current Opinion in Anaesthesiology·Tina L Palmieri
Jul 3, 2019·American Journal of Clinical Pathology·Amy E SchmidtMajed A Refaai
Dec 6, 2019·Shock·Robert L BallJeffrey W Shupp
Feb 10, 2020·Journal of Burn Care & Research : Official Publication of the American Burn Association·Kang GengHong Yan
Jun 17, 2020·Clinical Hemorheology and Microcirculation·Csaba LoiblCsaba Csontos
Dec 13, 2019·Advances in Wound Care·Thomas Charles LangChristopher John Jackson
Jun 23, 2018·Journal of Burn Care & Research : Official Publication of the American Burn Association·Nuria MartínMaria J Colomina
Aug 13, 2020·JGH Open : an Open Access Journal of Gastroenterology and Hepatology·Bernd FroesslerRajvinder Singh
May 26, 2018·Scars, Burns & Healing·Nicholas J MarsdenIain S Whitaker
Aug 7, 2010·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·David R KingDavid M Andrews
Oct 17, 2017·Burns : Journal of the International Society for Burn Injuries·Jeffrey W ShuppSaulius Butenas
Aug 24, 2020·Journal of the American Academy of Dermatology·Chun-Bing ChenUNKNOWN Taiwan Severe Cutaneous Adverse Reaction Consortium
May 8, 2021·Burns : Journal of the International Society for Burn Injuries·Jian-Chang LinXiao-Dong Chen
Jun 28, 2021·Burns : Journal of the International Society for Burn Injuries·Ruilong ZhaoChristopher Jackson

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.