Early cognitive development in children born to women with epilepsy: a prospective report

Epilepsia
R L BromleyLiverpool and Manchester Neurodevelopment Group [LMNDG]

Abstract

In this prospective study the early cognitive development of children born to women with epilepsy (n = 198) was assessed and compared to a group of children representative of the general population (n = 230). The children were assessed when younger than the age of 2 years using the Griffiths Mental Development Scales, either in their local participating hospital or in their home. The assessments were completed by an assessor who was blinded to whether the child's mother had epilepsy and to antiepileptic drug type. Children exposed to sodium valproate had a statistically significant increased risk of delayed early development in comparison to the control children. Linear regression analysis showed a statistically significant effect of sodium valproate exposure on the child's overall developmental level that was not accounted for by confounding variables. Delayed early development is also noted for children within an ad hoc group of less commonly utilized antiepileptic drugs, although conclusions cannot be drawn due to the size of this group (n = 13). Children exposed to either carbamazepine or lamotrigine in utero did not differ significantly in their overall developmental ability. Differences noted in specific developmental are...Continue Reading

References

May 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·H Nelson, N Nelson
Jun 22, 1989·The New England Journal of Medicine·K L JonesJ Adams
Dec 1, 1996·Archives of Disease in Childhood·A Ornoy, E Cohen
Jul 7, 2000·Journal of Medical Genetics·S J MooreJ C Dean
Oct 20, 2004·Journal of Neurology, Neurosurgery, and Psychiatry·N AdabD W Chadwick
Mar 23, 2005·Neurology·J VintenUNKNOWN Liverpool and Manchester Neurodevelopment Study Group
May 25, 2007·Journal of the International Neuropsychological Society : JINS·Elisa Kantola-SorsaMarit Korkman
Oct 19, 2007·Epilepsia·Sanjeev V ThomasP S Sarma
Jan 8, 2008·Developmental Medicine and Child Neurology·Karl TitzeHans-Christoph Steinhausen
Mar 19, 2008·Epilepsy & Behavior : E&B·Sanjeev V ThomasP S Sarma
Dec 3, 2008·Neurology·R L BromleyUNKNOWN Liverpool and Manchester Neurodevelopment Group
Mar 25, 2009·Archives of Disease in Childhood·R AckersI C K Wong
Apr 17, 2009·The New England Journal of Medicine·Kimford J MeadorUNKNOWN NEAD Study Group
Jun 18, 2009·Current Opinion in Neurology·Rebecca L BromleyKimford J Meador
Dec 29, 2009·Seizure : the Journal of the British Epilepsy Association·G MawerUNKNOWN Liverpool & Manchester Neurodevelopment Group

❮ Previous
Next ❯

Citations

Apr 6, 2011·Current Neurology and Neuroscience Reports·Susan Palac, Kimford J Meador
Feb 2, 2012·Developmental Neuropsychology·Caroline NadebaumAmanda Wood
Jan 13, 2011·Brain : a Journal of Neurology·Kimford J MeadorUNKNOWN NEAD Study Group
Jan 26, 2011·Neurology·R ShallcrossUNKNOWN UK Epilepsy and Pregnancy Register
Apr 12, 2012·Neurology·K J MeadorUNKNOWN NEAD Study Group
May 16, 2013·CNS Drugs·Athanasios Gaitatzis, Josemir W Sander
Sep 4, 2015·Expert Opinion on Drug Safety·Alberto VerrottiGaetano Zaccara
Feb 21, 2016·Seizure : the Journal of the British Epilepsy Association·Sinéad MurphyColin P Doherty
Jun 21, 2011·Epilepsy & Behavior : E&B·Rebecca L BromleyKimford J Meador
May 7, 2011·Epilepsy & Behavior : E&B·Kimford J MeadorDavid W Loring
May 17, 2011·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Khalid HamandiSuresh Muthukumaraswamy
Mar 31, 2015·Seizure : the Journal of the British Epilepsy Association·D McCorry, R Bromley
Mar 1, 2012·Seizure : the Journal of the British Epilepsy Association·E MawhinneyJ Morrow
Jul 19, 2011·Epilepsy & Behavior : E&B·Martin J BrodieH Steve White
Feb 20, 2015·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Naymee J Velez-Ruiz, Kimford J Meador
Jul 19, 2011·Seizure : the Journal of the British Epilepsy Association·Sophie KulagaAnick Bérard
May 8, 2014·Reproductive Toxicology·A VerrottiG M Tiboni
Jun 25, 2013·Clinical Biochemistry·Radu M Nanau, Manuela G Neuman
Jul 19, 2012·Lancet Neurology·Torbjörn Tomson, Dina Battino
Jul 27, 2012·Lancet Neurology·Piero Perucca, Frank G Gilliam
Oct 28, 2016·Seizure : the Journal of the British Epilepsy Association·Rebecca L Bromley, Gus A Baker
May 5, 2017·Experimental Neurology·Chiara Nicolini, Margaret Fahnestock
Apr 21, 2017·Neurochemical Research·Marissa Kellogg, Kimford J Meador
Nov 28, 2013·Pharmaceuticals·Bengt KällénMargareta Reis
Oct 31, 2014·The Cochrane Database of Systematic Reviews·Rebecca BromleyAnthony G Marson
Feb 6, 2018·Irish Journal of Medical Science·Hamizah Mohd Yunos, Andrew Green
Aug 1, 2019·The Journal of Nervous and Mental Disease·Nirmeen KishkSara Heneidy
Aug 9, 2019·Neurology·Torbjörn TomsonUNKNOWN EURAP Study Group
Mar 29, 2018·Journal of Neurology, Neurosurgery, and Psychiatry·Arron S LaceyMark I Rees
May 16, 2020·Frontiers in Neurology·Rebecca Spiegel, Heidy Merius
Apr 25, 2018·Practical Neurology·Sanjay M Sisodiya, UNKNOWN Epilepsy Advisory Group for the Association of British Neurologists
Oct 1, 2011·Therapeutic Advances in Drug Safety·Lisa Forsberg, Katarina Wide
Dec 29, 2018·Current Neuropharmacology·Michele RomoliCinzia Costa
Feb 13, 2019·CNS Drugs·Anna SerafiniPhilippe Gelisse

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The New England Journal of Medicine
Kimford J MeadorNEAD Study Group
Journal of Neurology, Neurosurgery, and Psychiatry
N AdabD Chadwick
The New England Journal of Medicine
Janneke JentinkEUROCAT Antiepileptic Study Working Group
© 2021 Meta ULC. All rights reserved