Early coronary angiogenesis in response to thyroxine: growth characteristics and upregulation of basic fibroblast growth factor

Circulation Research
Robert J TomanekA Sandra

Abstract

Although a substantial coronary angiogenesis occurs after thyroid hormone treatment, its regulation and relationship to cardiac hypertrophy are not understood. This study was designed to determine (1) the onset of capillary proliferation, (2) the sites of capillary proliferation, and (3) whether basic fibroblast growth factor (bFGF) upregulation occurs in response to thyroxine administration. Male Sprague-Dawley rats were injected daily with L-thyroxine (T4, 0.2 mg/kg s.c.). Bromodeoxyuridine labeling of capillary endothelial cells increased during the first 24 hours of treatment and peaked after 2 days of treatment. Northern blot analysis revealed a slight increase in bFGF mRNA during this period, followed by a doubling of expression by 48 hours, at which time bFGF protein was also increased. In situ hybridization, used to localize bFGF mRNA, showed an increase in transcripts within 24 hours after T4. This enhancement was uniform in the epimyocardium and endomyocardium. Histochemical analysis (double staining for alkaline phosphatase and dipeptidyl peptidase) of frozen sections, used to discriminate capillary profiles as arteriolar and venular, respectively, showed that growth occurred in the latter, since the percentage of ca...Continue Reading

References

May 18, 1978·Nature·S K Srivastava, N H Ansari
Apr 1, 1992·The American Journal of Physiology·R V YelamartyJ Y Cheung
Jan 1, 1989·Annual Review of Biochemistry·W H Burgess, T Maciag
Jan 1, 1988·The American Journal of Physiology·R G GayS Goldman
Apr 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·P F DaviesM A Gimbrone
Jan 1, 1980·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·C Craft-Cormney, J T Hansen
Mar 1, 1983·Progress in Cardiovascular Diseases·E MorkinS Goldman
Aug 1, 1995·Developmental Dynamics : an Official Publication of the American Association of Anatomists·A RatajskaR J Tomanek
Dec 1, 1994·The American Journal of Physiology·Y ChenR J Tomanek
Jun 1, 1995·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·M C Killingsworth
Feb 23, 1995·Molecular and Cellular Biochemistry·R R PaduaE Kardami
Feb 1, 1995·The American Journal of Physiology·S P Fauteck, S C Kandarian
Apr 1, 1994·The American Journal of Physiology·E F UngerS E Epstein
May 30, 1998·The Anatomical Record·R J Tomanek, T L Busch

❮ Previous
Next ❯

Citations

Dec 18, 2001·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·M Novatchkova, F Eisenhaber
Apr 6, 2004·Molecular and Cellular Endocrinology·Margaret C EggoSpencer Campbell
Mar 17, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Yingheng LiuA Martin Gerdes
Sep 2, 2010·Circulation·Daniela TirziuMichael Simons
Oct 4, 2011·PloS One·Olga V SavinovaA Martin Gerdes
Feb 19, 2011·Journal of Cardiothoracic and Vascular Anesthesia·Robert J Deegan, William R Furman
Jan 11, 2011·Journal of Molecular and Cellular Cardiology·Reza ArsanjaniSteven Goldman
Oct 24, 2009·Vascular Pharmacology·Yingheng LiuA Martin Gerdes
Oct 8, 2009·Vascular Pharmacology·Toshihiro Ichiki
Sep 23, 2008·Vascular Pharmacology·Daniela Tirziu, Michael Simons
May 6, 2008·Pharmacology & Therapeutics·Constantinos PantosDennis Cokkinos
Apr 24, 2008·The Journal of Steroid Biochemistry and Molecular Biology·Constantinos PantosDennis V Cokkinos
Jun 12, 2012·Journal of Cellular and Molecular Medicine·Jinghai ChenA Martin Gerdes
Nov 5, 2016·Nature Reviews. Cardiology·Avais JabbarSalman Razvi
Nov 5, 2016·Thyroid : Official Journal of the American Thyroid Association·Federica MarelliLuca Persani
Oct 29, 2009·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Liqun ZhangHans Georg Kuhn
Feb 14, 2019·AAPS PharmSciTech·Aishwarya Satish, Purna Sai Korrapati
Mar 4, 2008·American Journal of Physiology. Heart and Circulatory Physiology·Yingheng LiuA Martin Gerdes
Apr 10, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Wei ZhengRobert J Tomanek
Oct 18, 2007·Current Opinion in Endocrinology, Diabetes, and Obesity·Allan J WilliamsGraham R Williams
Jan 22, 2010·Expert Opinion on Pharmacotherapy·Neel R SodhaFrank W Sellke
Apr 14, 2016·Nanoscale·Sudip Mukherjee, Chitta Ranjan Patra
Mar 22, 2019·Frontiers in Cardiovascular Medicine·Rajinikanth GogirajuKatrin Schäfer
Nov 13, 2015·Journal of Atherosclerosis and Thrombosis·Toshihiro Ichiki
May 11, 2017·Archives of Endocrinology and Metabolism·Uğur CanpolatSinan Aydoğdu
Nov 5, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Xinguo WangRobert J Tomanek
Sep 17, 2009·American Journal of Physiology. Endocrinology and Metabolism·Paul J DavisMary K Luidens
Jul 3, 2021·International Journal of Molecular Sciences·Olga V BalberovaRegina F Nasyrova

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiomegaly

Cardiomegaly, known as an enlarged heart, is a multifactorial disease with different pathophysiological mechanisms. Hypertension, pregnancy, exercise-induced and idiopathic causes are some mechanisms of cardiomegaly. Discover the latest research of cardiomegaly here.