Early course of microcirculatory perfusion in eye and digestive tract during hypodynamic sepsis.

Critical Care : the Official Journal of the Critical Care Forum
Andrius PranskunasE Christiaan Boerma

Abstract

The aim of the study was to evaluate and compare the microcirculatory perfusion during experimental sepsis in different potentially available parts of the body, such as sublingual mucosa, conjunctiva of the eye, and mucosa of jejunum and rectum. Pigs were randomly assigned to sepsis (n = 9) and sham (n = 4) groups. The sepsis group received a fixed dose of live Escherichia coli infusion over a 1-hour period (1.8 × 10(9)/kg colony-forming units). Animals were observed 5 hours after the start of E. coli infusion. In addition to systemic hemodynamic assessment, we performed conjunctival, sublingual, jejunal, and rectal evaluation of microcirculation by using Sidestream Dark Field (SDF) videomicroscopy at the same time points: at baseline, and at 3 and 5 hours after the start of live E. coli infusion. Assessment of microcirculatory parameters of convective oxygen transport (microvascular flow index (MFI) and proportion of perfused vessels (PPV)), and diffusion distance (perfused vessel density (PVD) and total vessel density (TVD)) was done by using a semiquantitative method. Infusion of E. coli resulted in a hypodynamic state of sepsis associated with low cardiac output and increased systemic vascular resistance despite fluid admin...Continue Reading

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Citations

Dec 25, 2012·Intensive Care Medicine·Andrius PranskunasE Christiaan Boerma
Jul 10, 2012·Critical Care : the Official Journal of the Critical Care Forum·Colin L Verdant
Dec 15, 2015·Critical Care : the Official Journal of the Critical Care Forum·Chun-Yu WuUNKNOWN NTUH Center of Microcirculation Medical Research
Jun 5, 2015·Critical Care : the Official Journal of the Critical Care Forum·Matthias Jacquet-LagrèzeStéphane Junot
Sep 27, 2013·Virulence·Daniel De BackerJean-Louis Vincent
Oct 13, 2016·Journal of Clinical Monitoring and Computing·E Christiaan Boerma, Thomas W L Scheeren
Oct 28, 2019·Journal of Clinical Monitoring and Computing·Jurate SimkieneAndrius Pranskunas
Jun 4, 2020·Anaesthesia and Intensive Care·Daniëlle Mh BeurskensJan-Willem Em Sels
Aug 23, 2017·BioMed Research International·Andrius PranskunasMarius Brazaitis
Apr 9, 2020·Annals of Intensive Care·Jurate SimkieneAndrius Pranskunas

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Statistical Package for Social Sciences ( SPSS

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