PMID: 9423885Jan 10, 1998Paper

Early cytokine and chemokine gene expression during Pseudomonas aeruginosa corneal infection in mice

Infection and Immunity
K A KernackiL D Hazlett

Abstract

Using a multiprobe RNase protection assay, we examined cytokine and chemokine mRNAs that were expressed after corneal infection with Pseudomonas aeruginosa in mice. Cytokines that were upregulated included interleukin-1alpha (IL-1alpha) and -1beta, IL-1 receptor antagonist, IL-6, IL-11, granulocyte colony-stimulating factor, granulocyte-macrophage colony-stimulating factor, macrophage colony-stimulating factor, stem cell factor, lymphotoxin beta, transforming growth factor beta1, and tumor necrosis factor alpha. Chemokine transcripts that were upregulated included Eotaxin; gamma-interferon-inducible protein 10; monocyte chemoattractant protein 1; macrophage inflammatory proteins 1alpha, 1beta, and 2; and RANTES. Peak expression of these cytokines and chemokines was observed between 1 and 3 days after infection. These responses returned to or approached baseline preinfection levels by 7 days after ocular challenge. Identification of the various cytokines and chemokines upregulated during corneal infection provides important information relevant to unraveling the pathogenesis induced by this bacterium and provides hope that specific molecules can be targeted for therapy.

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Citations

May 11, 1999·Immunology and Cell Biology·N ColeA J Husband
May 8, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sharon A McClellanLinda D Hazlett
Mar 23, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Dominic C VoonLawrence J Abraham
May 25, 2005·Liver International : Official Journal of the International Association for the Study of the Liver·Lily S SubrataLawrence J Abraham
Jun 21, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Xi HuangRonald P Barrett
Jan 2, 2007·Cornea·Jean-Jacques GicquelPaul Dighiero
Jan 29, 2000·Immunology and Cell Biology·N ColeA J Husband
Dec 19, 2001·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·D C VoonL J Abraham
Feb 22, 2003·Infection and Immunity·Nerida ColeMark Willcox
Mar 13, 2002·Paediatric Drugs·Serina StrettonMark D P Willcox
May 13, 2005·Journal of Medical Microbiology·Craig WinstanleyUNKNOWN Microbiology Ophthalmic Group
Apr 5, 2013·Veterinary Ophthalmology·Tara R RichardsJonathan LaMarre
Dec 14, 2015·Proteomes·Rachida BouhenniJames Bates
Apr 20, 2001·ILAR Journal·Brigitte A. CowellSuzanne M. J. Fleiszig
Jan 26, 2007·Cornea·Pei-Chen ChungChing-Hsi Hsiao
Apr 11, 2008·Clinical & Experimental Optometry : Journal of the Australian Optometrical Association·Timothy C Smith, Graham A Lee
Jan 6, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·L D HazlettX Rudner
Jan 7, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·K A KernackiL D Hazlett
Nov 16, 2019·Scientific Reports·Tao JinAbukar Ali
Oct 9, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Tong-Jun LinAndrew C Issekutz
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Jul 22, 2017·International Journal of Molecular Medicine·Litao GuoXiaobo Tan
Nov 9, 2018·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Sandamali A EkanayakaLinda D Hazlett
Nov 11, 2019·Comparative Immunology, Microbiology and Infectious Diseases·Jung-Hoon LeeUn-Hwan Ha
Jul 10, 1999·Clinical Microbiology Reviews·L R Hall, E Pearlman
Jun 8, 2021·Experimental Eye Research·Lawson Ung, James Chodosh
Jun 23, 2005·Veterinary Immunology and Immunopathology·Douglas D BannermanJayne C Hope

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