Early cytokine modulation after the rapid induction phase of sublingual immunotherapy with mite monomeric allergoids

International Journal of Immunopathology and Pharmacology
M Di GioacchinoE Cavallucci

Abstract

The influence of different treatment schedules of sublingual immunotherapy (SLIT) in activating IL-10-producing T-cells, crucial in inducing allergen-specific tolerance, is not completely understood. The present work was designed to evaluate allergen driven interleukin release by mononuclear cells in the early phase of SLIT, after application of different induction schemes. Twenty mite-allergic patients were enrolled, 10 (group A) treated with a traditional 98 day induction scheme and 10 (group B) with a 16 day scheme with monomeric allergoid vaccine. At the end of the induction phase, the cumulative doses taken by group A and group B patients were equivalent to 50.5 and 50.3 microg of mite group 1 allergens, respectively. The release of Th1-, Th2- and Treg-related interleukins was assessed in culture supernatants of 5 microg/ml Der-p1-stimulated mononuclear cells, isolated before and after the induction phases. No relevant treatment-related side effects were observed. Interleukin release was similar in the two groups at the enrolment. Non-stimulated and Der p 1 stimulated release of studied cytokines was similar in the two groups at enrolment. Der p 1 stimulation significantly increased IL-10 release (p<0.0002) after treatment...Continue Reading

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Citations

Jul 22, 2010·International Journal of Immunopathology and Pharmacology·R W D'AnneoP Falagiani
Nov 3, 2009·Therapeutic Advances in Respiratory Disease·Cevdet Ozdemir
Oct 13, 2012·International Journal of Immunopathology and Pharmacology·M Di GioacchinoC Petrarca
Jan 20, 2011·International Journal of Immunopathology and Pharmacology·G MazzoccoliG Vendemiale
Jul 22, 2010·International Journal of Immunopathology and Pharmacology·D De BerardisM Di Giannantonio
Aug 9, 2016·Clinical and Molecular Allergy : CMA·Claudia PetrarcaMario Di Gioacchino
Apr 1, 2009·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Deepsikha SrivastavaBhanu Pratap Singh

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