Early deaths in bloodstream infections: a population-based case series

Infectious Diseases
Keiju S K KontulaO Lyytikäinen

Abstract

A notable portion of deaths in bloodstream infections (BSI) have previously been shown to occur within 2 days after taking the first positive blood culture specimen. The aim of this study was to analyse patients' characteristics and causative pathogens of BSIs, leading to early deaths in order to explore possibilities for prevention. Patients with BSI in Helsinki and Uusimaa region (population = 1.5 million) in 2007 were identified from the National Infectious Disease Register (n = 2181) and their deaths within 2 days after the first positive blood culture from the Population Information System (n = 76). Of the early fatal BSIs, 42 (55%) were community-acquired (CA-BSI) and 34 (45%) healthcare-associated (HA-BSI). Charlson comorbidity index was moderate-to-high (index ≥ 3) in 71% of HA-BSIs and 60% of CA-BSIs. The most common pathogens in CA-BSIs were Streptococcus pneumoniae (29%) and Escherichia coli (24%) and in HA-BSIs Pseudomonas aeruginosa (24%) and Staphylococcus aureus (18%). The respiratory tract (50%) was the most common focus of infection. Empiric antimicrobial treatment was more often appropriate in CA-BSIs vs HA-BSIs (81% vs 41%, p < 0.001), but treatment delays were longer in CA-BSIs. The majority of the BSI patie...Continue Reading

References

Sep 13, 1995·JAMA : the Journal of the American Medical Association·L LeiboviciS D Pitlik
Jan 1, 1997·Scandinavian Journal of Infectious Diseases·G Pedersen, H C Schønheyder
May 1, 1999·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·K M MadsenH T Sørensen
Jan 17, 2002·The New England Journal of Medicine·E RiversUNKNOWN Early Goal-Directed Therapy Collaborative Group
Jul 1, 1962·Archives of Internal Medicine·M H JACOBSONO W DONNELLY
Nov 18, 2003·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·G PedersenH T Sørensen
Dec 13, 2006·Epidemiology and Infection·K B LauplandD L Church
Mar 6, 2007·Epidemiology and Infection·K SkogbergJ P Nuorti
Apr 25, 2007·Archives of Internal Medicine·Daniel Z UslanLarry M Baddour
Oct 28, 2008·The Journal of Hospital Infection·M KanervaUNKNOWN Prevalence Survey Study Group
Feb 14, 2009·The Journal of Hospital Infection·P MittM Maimets
Dec 15, 2010·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Mette SøgaardHenrik Carl Schønheyder
Apr 5, 2011·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Craig A UmscheidPatrick J Brennan
Apr 11, 2012·BMC Infectious Diseases·Ryan LenzKevin B Laupland
Apr 20, 2012·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·K SkogbergP Ruutu
Jan 31, 2013·Intensive Care Medicine·R P DellingerUNKNOWN Surviving Sepsis Campaign Guidelines Committee including The Pediatric Subgroup

❮ Previous
Next ❯

Citations

Feb 20, 2018·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·Keiju S K KontulaOuti Lyytikäinen
Jan 11, 2018·Journal of Infection Prevention·Sainfer AliyuElaine Larson
Nov 27, 2019·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Walter N HarringtonVladimir P Zharov
May 13, 2020·Journal of Clinical Medicine·Merel M C LambregtsMark G J de Boer
Dec 4, 2020·Open Forum Infectious Diseases·Jaclyn A CusumanoDeena R Altman
Nov 13, 2019·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·Winfried V Kern, Siegbert Rieg
Sep 22, 2021·Emerging Infectious Diseases·Keiju S K KontulaOuti Lyytikäinen

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bacterial Pneumonia (ASM)

Bacterial pneumonia is a prevalent and costly infection that is a significant cause of morbidity and mortality in patients of all ages. Here is the latest research.

Bacterial Pneumonia

Bacterial pneumonia is a prevalent and costly infection that is a significant cause of morbidity and mortality in patients of all ages. Here is the latest research.

Attention Disorders

Attention is involved in all cognitive activities, and attention disorders are reported in patients with various neurological diseases. Here are the latest discoveries pertaining to attention disorders.