Early debridement of second-degree burn wounds enhances the rate of epithelization--an animal model to evaluate burn wound therapies

The Journal of Burn Care & Rehabilitation
S C DavisW H Eaglstein

Abstract

The purpose of this study was to examine the rate of epithelization of second-degree burn wounds with use of two debridement times (early versus late). Burn wounds were randomly assigned to one of the following treatment groups: (1) control, no debridement, (2) early debridement at 24 hours after burning, or (3) late debridement at 96 hours after burning. Wounds from each treatment group were harvested, incubated to allow separation of the dermis and epidermis, and then examined macroscopically for complete epithelization. On day 7 after burning, the percentage of burn wounds completely epithelized was as follows: nondebrided, 41%, 24-hour early debridement, 75%, and 96-hour late debridement, 22%. Burn wounds that were excised 24 hours after burning enhanced the rate of healing as compared to 96 hour and nondebrided burn wounds.

Citations

Oct 19, 2005·Archives of Dermatological Research·Stephen C DavisPatricia M Mertz
May 15, 2001·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·T P SullivanP Mertz
Jun 9, 2014·Burns : Journal of the International Society for Burn Injuries·Shi-Yuan SheuChun-Hsu Yao
Oct 29, 2015·Burns : Journal of the International Society for Burn Injuries·Adam J SingerVivek Raut
Oct 30, 2009·Burns : Journal of the International Society for Burn Injuries·Xue-Qing WangRoy M Kimble
Oct 11, 2008·Burns : Journal of the International Society for Burn Injuries·Xue-Qing WangRoy M Kimble
Jan 9, 2009·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Xue-Qing WangRoy M Kimble
Mar 13, 2010·The British Journal of Dermatology·L TangJ Li
Jul 4, 2015·Burns : Journal of the International Society for Burn Injuries·David M BurmeisterRobert J Christy
Jul 21, 2016·Journal of Burn Care & Research : Official Publication of the American Burn Association·Jimmy ToussaintAdam J Singer
Jul 28, 2010·Journal of Burn Care & Research : Official Publication of the American Burn Association·Adam J SingerLior Rosenberg
Oct 8, 2011·Journal of Burn Care & Research : Official Publication of the American Burn Association·Adam J SingerLior Rosenberg
Aug 25, 2020·Journal of Burn Care & Research : Official Publication of the American Burn Association·Angela L F GibsonLauren T Moffatt
Oct 25, 2017·Advances in Wound Care·Peter D'Arpa, Kai P Leung

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