Early Degeneration of Extracellular Matrix Used for Aortic Reconstruction During the Norwood Operation

The Annals of Thoracic Surgery
Ersin ErekEnder Odemis

Abstract

The use of prosthetic patch material is often required during the surgical reconstruction of complex congenital cardiac malformations. Decellularized porcine small intestinal submucosa, a type of extracellular matrix, was recently introduced as a patch for cardiac and vascular tissue repair. Extracellular matrix was used for aortic reconstruction during the Norwood procedure in 8 consecutive neonates with hypoplastic left heart syndrome. Rapid degeneration or aneurysm formation developed in 3 of these patients who came to second-stage surgery. Extracellular matrix should be used cautiously for aortic reconstruction in infants until additional reports from other centers provide confirmation of its safety.

References

Oct 8, 2011·Interactive Cardiovascular and Thoracic Surgery·Andrea QuartiMarco Pozzi
Aug 25, 2012·The Journal of Thoracic and Cardiovascular Surgery·Lorenzo BoniV Mohan Reddy
Jul 3, 2013·Journal of Vascular Surgery·Steven S WeberCharles L Mesh

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Citations

Oct 19, 2016·Journal of Vascular Surgery·Nikola DobrilovicJaishankar Raman
Feb 15, 2017·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Marek KaweckiAleksandra Kasperczyk
Dec 15, 2019·World Journal for Pediatric & Congenital Heart Surgery·Bahar TemurErsin Erek
Aug 29, 2018·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·R Scott BakerDavid L S Morales
Jun 15, 2018·Frontiers in Pediatrics·Antonio F CornoBranko Mimic
May 1, 2020·Frontiers in Cardiovascular Medicine·Andras P DurkoJolanda Kluin
Nov 24, 2020·Journal of Cardiac Surgery·Mehmet A OnalanErsin Erek
Oct 26, 2020·The Annals of Thoracic Surgery·Vikram SoodRichard G Ohye

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