Early detection and monitoring of chronic wounds using low-cost, omniphobic paper-based smart bandages

Biosensors & Bioelectronics
Aniket PalRamses V Martinez

Abstract

The growing socio-economic burden of chronic skin wounds requires the development of new automated and non-invasive analytical systems capable of wirelessly monitoring wound status. This work describes the low-cost fabrication of single-use, omniphobic paper-based smart bandages (OPSBs) designed to monitor the status of open chronic wounds and to detect the formation of pressure ulcers. OPSBs are lightweight, flexible, breathable, easy to apply, and disposable by burning. A reusable wearable potentiostat was fabricated to interface with the OPSB simply by attaching it to the back of the bandage. The wearable potentiostat and the OPSB can be used to simultaneously quantify pH and uric acid levels at the wound site, and wirelessly report wound status to the user or medical personnel. Additionally, the wearable potentiostat and the OPSBs can be used to detect, in an in-vivo mouse model, the formation of pressure ulcers even before the pressure-induced tissue damage becomes visible, using impedance spectroscopy. Our results demonstrate the feasibility of using inexpensive single-use OPSBs and a reusable, wearable potentiostat that can be easily sterilized and attached to a new OPSB during the dressing change, to provide long term w...Continue Reading

Associated Clinical Trials

Citations

Mar 1, 2020·Micromachines·Xudong Yang, Huanyu Cheng
Jul 14, 2020·Journal of Wound Care·Suzanne O'CallaghanRosemarie Derwin
Sep 27, 2019·Current Pharmaceutical Design·Gitika A DhingraManju Nagpal
Feb 6, 2021·Biosensors & Bioelectronics·Sidharth ModhaHideaki Tsutsui
Mar 16, 2021·Analytical Chemistry·Yuqiu WangBingbing Gao
Nov 1, 2020·Biosensors & Bioelectronics·Jihong MinWei Gao
Apr 23, 2021·Journal of Nanobiotechnology·Wei-Hsuan SungChao-Min Cheng
Jun 16, 2021·Advances in Wound Care·Maximillian A WeigeltIra M Herman
Jun 25, 2021·Advanced Healthcare Materials·Kaiyi ZhangXiaodong Chen
Jul 20, 2021·IScience·Yadong XuZheng Yan
Jul 27, 2021·Advanced Healthcare Materials·Ning TangHossam Haick
Jun 25, 2020·ACS Applied Materials & Interfaces·Laicong QiaoGuozhen Liu
Aug 25, 2018·ACS Applied Materials & Interfaces·Behnam SadriRamses V Martinez
Nov 12, 2020·ACS Sensors·Olja SimoskaKeith J Stevenson

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