Early detection of HIV infection among Kenyan infants using a reverse transcriptase activity assay.

The Pediatric Infectious Disease Journal
Sumathi SivapalasingamFred Valentine

Abstract

Two hundred HIV-exposed Kenyan infants were tested for HIV infection at birth and at age 6, 12, 24 and 48 weeks, by DNA polymerase chain reaction (PCR) and Cavidi reverse transcriptase (RT) assays and after age 18 months by HIV antibody test. Eleven (5.5%) infants became HIV infected. In 6 infants, positive RT preceded positive DNA PCR. The use of RT assay may facilitate earlier HIV diagnosis in infants.

References

Jun 15, 2007·Journal of Tropical Pediatrics·Sumathi SivapalasingamShaffiq Essajee
Dec 7, 2007·Pediatrics·Jennifer S Read, UNKNOWN Committee on Pediatric AIDS, American Academy of Pediatrics
Mar 20, 2009·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Vladimir NovitskyM Essex
Jul 21, 2009·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Vicki GreengrassSuzanne M Crowe
Sep 14, 2010·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Paul StewartSusan A Fiscus
Jan 8, 2011·AIDS and Behavior·Amin S HassanJames A Berkley

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