Early Detection of Learning Difficulties when Confronted with Novel Information in Preclinical Alzheimer's Disease Stage 1

Journal of Alzheimer's Disease : JAD
Adrià Tort-MerinoLorena Rami

Abstract

We employed a highly demanding experimental associative learning test (the AFE-T) to explore memory functioning in Preclinical Alzheimer's Disease stage 1 (PreAD-1) and stage 2 (PreAD-2). The task consisted in the learning of unknown object/name pairs and our comprehensive setup allowed the analysis of learning curves, immediate recall, long-term forgetting rates at one week, three months, and six months, and relearning curves. Forty-nine cognitively healthy subjects were included and classified according to the presence or absence of abnormal CSF biomarkers (Control, n = 31; PreAD-1, n = 14; PreAD-2, n = 4). Control and PreAD-1 performances on the experimental test were compared by controlling for age and education. These analyses showed clear learning difficulties in PreAD-1 subjects (F = 6.98; p = 0.01). Between-group differences in long-term forgetting rates were less notable, reaching statistical significance only for the three-month cued forgetting rate (F = 4.83; p = 0.03). Similarly, relearning sessions showed only statistical trends between the groups (F = 3.22; p = 0.08). In the whole sample, significant correlations between CSF Aβ42/tau ratio and the AFE-T were found, both in the total learning score (r = 0.52; p < 0...Continue Reading

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Citations

Sep 25, 2018·Aging & Mental Health·María Gómez-Gallego, Juan Gómez-García
Aug 28, 2019·Brain Sciences·Elena ChipiLucilla Parnetti
Dec 29, 2020·Annals of Clinical and Translational Neurology·Adrià Tort-MerinoAntoni Rodríguez-Fornells
Apr 2, 2021·International Journal of Geriatric Psychiatry·Adrià Tort-MerinoLorena Rami

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