Early detection of left ventricular dysfunction with strain imaging in thalassemia patients.

Clinical Cardiology
Ahmet Kaya BilgeSelim Yavuz

Abstract

Iron-mediated cardiomyopathy is the main cause of death in thalassemia patients. Early detection of cardiac abnormalities is important as aggressive chelation therapy may improve prognosis in these patients. The aim of this study is to evaluate left ventricular (LV) functions by tissue velocity imaging (TVI) and strain imaging (SI) in thalassemia patients without overt heart failure. At total of 32 patients with beta-thalassemia major (mean age: 24.2+/-8.0 y, 22 male) and 25 healthy controls (mean age: 22.8+/-2.1 y, 20 male) were included. Conventional echocardiography, TVI, and SI were performed on all subjects. Tissue velocity imaging and SI measures included peak systolic, early and late diastolic myocardial velocities, peak systolic strain and strain rate, and early and late diastolic strain rate at the basal segments of the LV lateral and septal walls. There were no significant differences in LV ejection fraction and fractional shortening between the groups. However, systolic myocardial velocity of the lateral wall and systolic strain and strain rate of the septal and lateral walls were significantly lower in thalassemia patients. There was a significant negative correlation between LV mass index and systolic myocardial ve...Continue Reading

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Citations

Aug 18, 2012·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Ines MonteMaria Antonietta Romeo
Oct 23, 2012·Asian Cardiovascular & Thoracic Annals·Noor Mohammad NooriMosaeib Shahriar
Aug 2, 2018·BMC Anesthesiology·Sonal SharmaDmitri Bezinover
Nov 16, 2011·Circulation·Dimitrios T Kremastinos, Dimitrios Farmakis
Dec 12, 2018·Journal of Pediatric Hematology/oncology·Mohammed El-ShanshoryMohamed El-Gamasy
Apr 15, 2020·Journal of Pediatric Hematology/oncology·Kandice MahEdythe B Tham
Nov 20, 2019·Indian Journal of Hematology & Blood Transfusion : an Official Journal of Indian Society of Hematology and Blood Transfusion·Osama Abdrabelrasool El RazakyEsraa Ahmed El-Dosoky
Apr 12, 2019·Pediatric Cardiology·Yiu-Fai CheungShau-Yin Ha
Dec 22, 2016·European Journal of Heart Failure·Dimitrios FarmakisJohn Parissis

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