Early detection of lung cancer by molecular markers in endobronchial epithelial-lining fluid

Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer
Nicolas KahnRuprecht Kuner

Abstract

Early detection of malignancies in the lung by less-invasive methods aims at achieving efficient intervention and subsequently a reduction of the high mortality rate. We investigated whether biomarker analysis in endobronchial epithelial-lining fluid (ELF) collected by bronchoscopic microsampling (BMS) may be useful for a definitive preoperative diagnosis. ELF was collected from subsegmental bronchi close to the indeterminate pulmonary nodule, which was detected by computed tomography, and from the contralateral lung. Diagnosis was confirmed by transbronchial biopsy or surgery. The study includes 142 ELF samples from 51 non-small-cell lung cancer patients and 20 benign cases. Microarray analysis was done with a patient subset (n = 15) to narrow down genes associated with a malignant phenotype. Thirteen potential biomarkers have been further analyzed by quantitative real-time polymerases chain reaction in an independent patient cohort (n = 56). All patients underwent BMS without complications. Gene-expression analyses by microarrays and quantitative real-time polymerases chain reaction could be reliably applied to ELF samples, and resulted in potential biomarkers for malignant pulmonary nodules. Four genes (tenascin-C, [C-X-C mo...Continue Reading

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Citations

Jul 22, 2014·Frontiers in Biology·Wei Bin FangNikki Cheng
Jan 1, 2013·Microarrays·Ruprecht Kuner
Dec 14, 2017·BMC Pulmonary Medicine·Akifumi UchidaHiromasa Inoue
Mar 12, 2016·Oncotarget·Florian GebauerMichael Tachezy
Apr 9, 2021·Nitric Oxide : Biology and Chemistry·Lara M F GuimarãesClaudiana Lameu

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