Early detection of metachronous brain metastases by biannual brain MRI follow-up may provide patients with non-small cell lung cancer with more opportunities to have radiosurgery

Clinical Neurology and Neurosurgery
Tomofumi NishikawaKohsuke Yamashita

Abstract

Those who have brain metastases smaller than 30 mm in diameter and less than 5 in number can be treated less invasively with radiosurgery. This retrospective study evaluated the optimal brain magnetic resonance image (MRI) follow-up interval for non-small cell lung cancer (NSCLC) patients to detect radiosurgically manageable metachronous brain metastases (MBM). The records of 551 patients with primary NSCLC, treated in our institute between 2002 and 2007, were reviewed. The initial brain MRI was performed within one month after diagnosis of NSCLC, and the follow-up brain MRI interval was at the discretion of physicians. The interval between the last MRI in which brain metastases were not found and the first MRI in which brain metastases were found was defined as the critical MRIs interval (CMI). The relationship between CMI and the maximum size or number of MBM was evaluated. Among reviewed patients, the initial MRI of 38 patients showed brain metastases and 29 patients were diagnosed as MBM. In these MBM patients, the median interval from diagnosis of NSCLC to diagnosis of brain metastases was 8.9 months. The median CMI was 4.7 (range: 1.6-18.9) months. All brain metastases smaller than 30 mm in maximum diameter were found whe...Continue Reading

References

Jan 1, 1992·International Journal of Radiation Oncology, Biology, Physics·B G FullerM A Bagshaw
Mar 1, 1994·International Journal of Radiation Oncology, Biology, Physics·J C FlickingerP K Sneed
Mar 17, 1999·International Journal of Radiation Oncology, Biology, Physics·P K SneedD A Larson
Apr 18, 2003·Neurosurgery·Johannes LutterbachChristoph B Ostertag
Jul 1, 2004·Surgical Neurology·Jason SheehanL Dade Lunsford
Mar 1, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Harvey J MamonRaphael Bueno
Jun 14, 2005·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Hannah CarolanFrances Shepherd
Sep 2, 2005·Health Affairs·Gerard F AndersonHugh R Waters
Aug 26, 2006·Clinical Neurology and Neurosurgery·Ki-Young KwonJong Hyun Kim
Aug 7, 2007·International Journal of Radiation Oncology, Biology, Physics·Hidefumi AoyamaHiroki Shirato
Nov 1, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Christoph PöttgenMartin Stuschke
Jul 1, 2008·Clinical Neurology and Neurosurgery·William S AndersonDaniele Rigamonti
Oct 8, 2008·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Si-Yu WangHua Yang
Jun 6, 2009·Stereotactic and Functional Neurosurgery·Ajay NiranjanL Dade Lunsford

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