Early detection of premalignant conditions in the colon by fluorescence endoscopy using local sensitization with hexaminolevulinate

Endoscopy
B MayingerD Schwab

Abstract

We aimed to determine the feasibility of obtaining selective fluorescence of precancerous/cancerous lesions in the colon with a new fluorescence video endoscope system in combination with the selective photosensitizer precursor hexaminolevulinate (HAL), and to carry out a dose-finding study with evaluation of the optimal dose and application time. 12 patients with colorectal lesions underwent sensitization with locally applied HAL enemas in two concentrations (0.8 mmol and 1.6 mmol). The examination was conducted either 30 or 60 minutes after rectal administration of the sensitizer, using a special light source capable of delivering either white or blue excitation light. Red fluorescence induced by illumination with blue light was detected via a prototype fluorescence video colonoscope. Biopsies were taken from suspicious areas found with white or blue light. Corresponding endoscopic, fluorescence, and microscopic findings were compared. Using histological findings as the gold standard, 52/53 of the premalignant/malignant lesions showed red fluorescence under the photodynamic diagnosis (PDD) examination; 38/53 were detected with white-light endoscopy. The PDD mode showed 28 % more polyps than did white-light endoscopic imaging....Continue Reading

Citations

May 29, 2009·Current Opinion in Gastroenterology·Martin Goetz, Ralf Kiesslich
Dec 24, 2011·Gastroenterology Research and Practice·Hiroyuki AiharaTakeshi Suzuki
Apr 29, 2010·Der Internist·M GoetzR Kiesslich
Dec 23, 2009·Gastroenterology·Umar Mahmood
Aug 18, 2009·Gastroentérologie Clinique Et Biologique·R Lambert
Jul 13, 2013·Biomedical Optics Express·Riccardo CicchiFrancesco S Pavone
Jun 15, 2017·Nature Reviews. Gastroenterology & Hepatology·Arthur HoffmanRalf Kiesslich
Jan 27, 2016·World Journal of Gastroenterology : WJG·Markus BrücknerDominik Bettenworth

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