PMID: 16639167Apr 28, 2006Paper

Early detection of schizophrenia

Current Opinion in Psychiatry
Richard Drake, Shon Lewis

Abstract

This article will evaluate the rationale and feasibility of detecting psychosis and schizophrenia earlier than is currently the case. Schizophrenia incidence may vary more than has been believed previously. Early detection studies fall into two groups. Firstly, operational criteria now exist for prodromal or at risk mental states which predict transition to psychosis of 20-40% over 1 year. The first randomized trials of antipsychotic drug and psychological interventions aimed at reducing this transition rate have shown promising results. Secondly, duration of untreated psychosis in the first episode seems genuinely to be associated with clinical outcome but how much of the association is truly causal remains disputed. Shortening duration of untreated psychosis by early detection of full psychosis appears feasible but its benefits are not yet unequivocally demonstrated.

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Citations

Dec 26, 2012·Social Psychiatry and Psychiatric Epidemiology·Gertrud J FridgenAnita Riecher-Rössler
Oct 21, 2009·PLoS Medicine·Mari Jair de JesusGraham Thornicroft
Sep 8, 2009·Biological Psychiatry·Anita Riecher-RösslerRolf-Dieter Stieglitz
Jan 25, 2007·Acta Psychiatrica Scandinavica·A Riecher-RösslerR-D Stieglitz
Jan 21, 2006·Acta Psychiatrica Scandinavica·R CarlssonJ Cullberg
Feb 24, 2006·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Michael RutterBarbara Maughan
Mar 26, 2011·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Michael Rutter
Jul 11, 2012·Early Intervention in Psychiatry·Eric V StroblShyam Visweswaran
Dec 19, 2013·PloS One·Sarah HardoonDavid P J Osborn
Feb 7, 2007·Current Opinion in Psychiatry·Eóin Killackey, Alison R Yung
Jun 7, 2007·Current Opinion in Psychiatry·George C PattonPatrick McGorry
Mar 23, 2010·International Clinical Psychopharmacology·Alfredo Carlo AltamuraBernardo Dell'Osso
Jul 11, 2007·Epidemiologia e psichiatria sociale·Eóin KillackeyPatrick D McGorry
Nov 28, 2007·The Medical Journal of Australia·Patrick D McGorryAlison R Yung

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