Nov 8, 2018

Early detonation by sprouted mossy fibers enables aberrant dentate network activity

BioRxiv : the Preprint Server for Biology
William D HendricksEric Schnell

Abstract

In temporal lobe epilepsy, sprouting of hippocampal mossy fiber axons onto dentate granule cells creates a recurrent excitatory network. Unlike mossy fibers projecting to CA3, these sprouted mossy fiber synapses display prominent short-term depression, which could limit their participation in epileptiform activity. However, we reveal that a lack of tonic adenosine-mediated inhibition at these synapses contributes to an elevated probability of glutamate release and enables reverberant circuit activity.

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Mentioned in this Paper

Biological Neural Networks
Presynaptic Terminals
CA3 Pyramidal Cell Area
Mossy Fibers, Hippocampal
Adenosine
Epilepsy
Neurons
Mossy Fiber
Beta-tricalcium Phosphate
Axon

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