PMID: 9160244May 1, 1997Paper

Early development of the oligodendrocyte in the embryonic chick metencephalon

Journal of Neuroscience Research
K OnoY Yasui

Abstract

It has been demonstrated that the spinal cord oligodendrocytes in the vertebrates arise in the ventral ventricular zone adjacent to the floor plate in their early development. Because of the similarities of basic structures in the spinal cord and metencephalon, it is probable that the mode of early oligodendrocyte development in the metencephalon is the same as that in the spinal cord. We examined this possibility in chick embryos, using monoclonal antibodies O1 and O4, markers for oligodendrocyte lineage. An O4-positive (O4+) cell focus was observed in the medial ventricular zone of E5 chick ventral metencephalon (the earliest stage examined), adjacent to the floor plate. At E6, O4+ cells were dispersed from the medial to the lateral pons and, at E7, to the cerebellar anlagen. O4+ cells in the E6 brainstem and in the E7 cerebellum were unipolar in shape, whereas one day later, some of the labeled cells were multipolar with a few thin processes. O1+ oligodendrocytes first appeared at E8 in the ventromedial part of the pons and were distributed throughout the pons at E10 and in the cerebellum at E12. Explants from three subdivisions of the metencephalon (medial and lateral pons, and cerebellum) from E5 to E8 chick embryos were s...Continue Reading

Citations

Dec 24, 2013·Acta histochemica·Ji Young KimJe Hoon Seo
Feb 27, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Denise A Zannino, Bruce Appel
Jun 17, 2015·Biochemical and Biophysical Research Communications·Masae NaruseYasuki Ishizaki
Sep 9, 2011·Glia·Nora MecklenburgSalvador Martinez
Dec 10, 1999·Developmental Biology·E M Perez VillegasS Martínez
Apr 9, 2004·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Andrew A Jarjour, Timothy E Kennedy
May 18, 2016·Nature Communications·Robert A LindquistArturo Alvarez-Buylla

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