Early developmental milestones in Duchenne muscular dystrophy

Developmental Medicine and Child Neurology
Paula van DommelenPaul H Verkerk

Abstract

To investigate the differences in attainment of developmental milestones between young males with Duchenne muscular dystrophy (DMD) and young males from the general population. As part of the case-control 4D-DMD study (Detection by Developmental Delay in Dutch boys with Duchenne Muscular Dystrophy), data on developmental milestones for 76 young males with DMD and 12 414 young males from a control group were extracted from the health care records of youth health care services. The characteristics of DMD were acquired from questionnaires completed by parents. Logistic regression analyses were performed with milestone attainment (yes/no) as the dependent variable and DMD (yes/no) as the independent variable, with and without adjustment for age at visit. The mean number of available milestones was 43 (standard deviation [SD]=13, range: 1-59) in the DMD group and 40 (SD=15, range: 1-60) in the control group. The presence of developmental delay was evident at 2 to 3 months of age, with a higher proportion of young males with DMD failing to attain milestones of gross/fine motor activity, adaptive behaviour, personal/social behaviour, and communication (range age-adjusted odds ratios [ORs]=2.3-4.0, p<0.01). Between 12 and 36 months of ...Continue Reading

References

Apr 7, 2000·Brain Research. Brain Research Reviews·M F Mehler
Oct 13, 2000·European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society·K MohamedP Nicolaides
May 4, 2004·European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society·Evelyn P ParsonsDon M Bradley
Sep 15, 2005·Health Economics·Frederik T Schut, Wynand P M M Van de Ven
Mar 11, 2006·American Journal of Medical Genetics. Part a·Lainie Friedman Ross
Apr 25, 2007·The Journal of Pediatrics·Shana E CyrulnikVeronica J Hinton
Mar 28, 2012·Annals of Neurology·Jerry R MendellRobert B Weiss
Jan 24, 2013·European Journal of Human Genetics : EJHG·Stuart J MoatLouise Hartley
Mar 29, 2013·Neuromuscular Disorders : NMD·Marika PaneEugenio Mercuri
May 29, 2013·Pediatrics·Garey H NoritzUNKNOWN Neuromotor Screening Expert Panel
Jul 22, 2014·Muscle & Nerve·Katharine BushbyUNKNOWN PTC124-GD-007-DMD STUDY GROUP
Aug 26, 2014·The Journal of Pediatrics·Kara T Mirski, Thomas O Crawford
Sep 5, 2014·Archives of Disease in Childhood·Henriette J A van RuitenMichela Guglieri
Jan 30, 2015·European Journal of Human Genetics : EJHG·Siaw H WongSylvia A Metcalfe
Oct 17, 2016·Journal of Pediatric Health Care : Official Publication of National Association of Pediatric Nurse Associates & Practitioners·Roxanna M Bendixen, Amy Houtrow
Apr 28, 2017·Orphanet Journal of Rare Diseases·S RyderJ Kleijnen
Feb 6, 2018·Lancet Neurology·David J BirnkrantUNKNOWN DMD Care Considerations Working Group

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Citations

Mar 21, 2021·Neuromuscular Disorders : NMD·Liang WangCheng Zhang
Aug 8, 2021·International Journal of Environmental Research and Public Health·Luuk van WelEelco Kuijpers

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