Early developmental outcomes following major noncardiac and cardiac surgery in term infants: a population-based study

The Journal of Pediatrics
Karen WalkerAndrew J A Holland

Abstract

To ascertain developmental differences between term infants after major noncardiac surgery and cardiac surgery compared with healthy control infants in New South Wales, Australia. This prospective population-based cohort study enrolled infants between August 1, 2006, and December 31, 2008, who required major noncardiac surgery within the first 90 days of life. Developmental outcomes were compared in these children, cohorts of term infants requiring cardiac surgery, and healthy controls. Infants were assessed at 1 year of age using the Bayley Scales of Infant and Toddler Development, Third Edition (BSID-III). Of the 784 infants enrolled, 688 (90.2%) of infants alive at 1 year were assessed. Of these, 539 infants were term and were included in the present analysis. Compared with controls, the infants who underwent cardiac surgery had significantly lower (P < .001) mean scores in all 5 BSID-III subscales, and the infants who underwent noncardiac surgery had significantly lower (P < .05) mean scores in 4 of the 5 BSID-III subscales. The greatest difference was in the incidence of gross motor delay in both the cardiac surgery group (OR, 0.25; 95% CI, 0.16-0.41) and the noncardiac surgery group (OR, 0.41; 95% CI, 0.26-0.63). This uni...Continue Reading

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Citations

Sep 14, 2012·Journal of Paediatrics and Child Health·Karen WalkerNadia Badawi
Dec 15, 2015·Journal of Pediatric Surgery·Karen WalkerUNKNOWN DAISy study
Oct 23, 2015·Journal of Pediatric Surgery·Emma L HarrisJan E Dickinson
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