PMID: 16509528Mar 3, 2006Paper

Early diabetic complications in a population of young patients with type 1 diabetes mellitus despite intensive treatment

Journal of Pediatric Endocrinology & Metabolism : JPEM
Maria NordwallJ Ludvigsson

Abstract

To describe the prevalence of early complications in an unselected population of patients with type 1 diabetes mellitus (DM1) diagnosed in childhood with intensive insulin treatment from diagnosis. Eighty children and adolescents with DM1, age 7-22 years and DM1 duration >3 years, were studied. Neuropathy was defined as abnormal nerve conduction finding in > or = 2 of 4 nerves (sural and peroneal nerves), nephropathy as albumin excretion rate > or = 20 microg/min and retinopathy as all grades of retinal changes in fundus photographs. The prevalence of neuropathy was 59%, of retinopathy 27% and of nephropathy 5% after 13 years DM1 duration. Mean (SD) long-term HbA1c was 8.4 (0.9)% (DCCT-corrected value). Even in a population with intensive insulin treatment from the beginning and fairly good metabolic control, the prevalence of subclinical neuropathy was high, while other diabetic complications were lower than usually reported.

References

Feb 1, 1983·Diabetes·R J YoungB F Clarke
Jun 1, 1995·Diabetologia·L HyllienmarkJ Ludvigsson
Jun 20, 1994·The Medical Journal of Australia·J M FairchildM Silink
Feb 19, 1998·Journal of Pediatric Endocrinology & Metabolism : JPEM·E BognettiG Chiumello
Oct 31, 1998·Diabetic Medicine : a Journal of the British Diabetic Association·M BojestigJ Ludvigsson
Jun 22, 2001·Journal of Child Neurology·A VerrottiF Chiarelli
Dec 18, 2001·The Journal of Pediatrics·N H WhiteUNKNOWN Diabetes Control and Complications Trial (DCCT)/Epidemiology of Diabetes Interventions and Complications (EDIC) Research Gro
Apr 30, 2002·Diabetes·Keith DrummondUNKNOWN International Diabetic Nephropathy Study Group
Mar 29, 2003·Diabetes Care·Peter HovindHans-Henrik Parving
Apr 30, 2003·Diabetes·Polly J BingleyPatricia W Mueller
Mar 27, 2004·Pediatric Diabetes·Daniela TrottaFrancesco Chiarelli

❮ Previous
Next ❯

Citations

Aug 20, 2010·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·M Loredana Marcovecchio, Francesco Chiarelli
Aug 30, 2008·BMJ : British Medical Journal·Patricia Herold GallegoKim C Donaghue
May 1, 2012·Survey of Ophthalmology·Sobha SivaprasadJennifer Evans
Jul 27, 2015·Pediatric Clinics of North America·Neil H White
Feb 9, 2013·Diabetes Research and Clinical Practice·Joanne T MoserTerri H Lipman
Apr 8, 2016·Cardiovascular Diabetology·Julia SzendroediUNKNOWN GDS Group
Aug 4, 2016·Journal of Pediatric Endocrinology & Metabolism : JPEM·A WeverD A Schott
Sep 23, 2016·Journal of Pediatric Endocrinology & Metabolism : JPEM·Stuart KeelLaima Brazionis
Oct 18, 2007·Current Opinion in Endocrinology, Diabetes, and Obesity

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diabetes & Tolerance

Patients with type I diabetes lack insulin-producing beta cells due to the loss of immunological tolerance and autoimmune disease. Discover the latest research on targeting tolerance to prevent diabetes.