Early diabetic retinopathy diagnosis based on local retinal blood vessel analysis in optical coherence tomography angiography (OCTA) images

Medical Physics
Nabila EladawiAyman El-Baz

Abstract

This paper introduces a new computer-aided diagnosis (CAD) system for detecting early-stage diabetic retinopathy (DR) using optical coherence tomography angiography (OCTA) images. The proposed DR-CAD system is based on the analysis of new local features that describe both the appearance and retinal structure in OCTA images. It starts with a new segmentation approach that has the ability to extract the blood vessels from superficial and deep retinal OCTA maps. The high capability of our segmentation approach stems from using a joint Markov-Gibbs random field stochastic model integrating a 3D spatial statistical model with a first-order appearance model of the blood vessels. Following the segmentation step, three new local features are estimated from the segmented vessels and the foveal avascular zone (FAZ): (a) vessels density, (b) blood vessel calibre, and (c) width of the FAZ. To distinguish mild DR patients from normal cases, the estimated three features are used to train and test a support vector machine (SVM) classifier with the radial basis function (RBF) kernel. On a cohort of 105 subjects, the presented DR-CAD system demonstrated an overall accuracy (ACC) of 94.3%, a sensitivity of 97.9%, a specificity of 87.0%, the area...Continue Reading

References

Sep 1, 1984·Archives of Ophthalmology·G H BresnickK Korth
Jul 9, 1999·Diabetes/metabolism Research and Reviews·A R Mire-SluisA Lernmark
Jan 31, 2003·Investigative Ophthalmology & Visual Science·Michael LarsenDavid R Owens
Sep 14, 2006·IEEE Transactions on Medical Imaging·João V B SoaresMichael J Cree
Jan 1, 1993·IEEE Transactions on Image Processing : a Publication of the IEEE Signal Processing Society·C Bouman, K Sauer
Jun 11, 2008·Archives of Ophthalmology·Thomas R HedgesMaria Luz Amaro-Quierza
Sep 26, 2008·IEEE Transactions on Medical Imaging·Mona K GarvinMilan Sonka
Feb 5, 2011·IEEE Transactions on Medical Imaging·Gwénolé QuellecMichael D Abramoff
Jan 1, 2010·IEEE Reviews in Biomedical Engineering·Michael D AbràmoffMilan Sonka
Apr 25, 2012·Computer Methods and Programs in Biomedicine·M M FrazS A Barman
Feb 2, 2013·IEEE Transactions on Bio-medical Engineering·Qiangfeng Peter LauTien Yin Wong
Jul 16, 2013·Computerized Medical Imaging and Graphics : the Official Journal of the Computerized Medical Imaging Society·Qazaleh MirsharifHamidreza Pourreza
Oct 11, 2013·Conference Proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society·Sohini RoychowdhuryKeshab K Parhi
Jul 16, 2014·IEEE Transactions on Medical Imaging·Hrvoje BogunovicXiaodong Wu
Sep 2, 2014·BMC Medical Informatics and Decision Making·Zhuo ZhangJiang Liu
Sep 23, 2014·Medical Image Analysis·George AzzopardiNicolai Petkov
Jan 7, 2016·Conference Proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society·Jorge OliveiraCarlos A Silva
Jan 7, 2016·Conference Proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society·Sohini RoychowdhuryKeshab K Parhi
Jan 25, 2016·Investigative Ophthalmology & Visual Science·Santosh G K GaddeAbhijit Sinha Roy
Nov 30, 2016·JAMA : the Journal of the American Medical Association·Varun GulshanDale R Webster
May 11, 2017·PloS One·Marion R MunkMartin S Zinkernagel
Aug 15, 2017·Computers in Biology and Medicine·Nabila EladawiAyman El-Baz
Sep 21, 2017·Frontiers in Bioscience (Landmark Edition)·Nabila EladawiAyman El-Baz
Jan 25, 2018·The British Journal of Ophthalmology·Harpal Singh SandhuAyman El-Baz

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