Early diagnosis followed by front-line autologous peripheral blood stem cell transplantation for patients affected by POEMS syndrome

Leukemia Research
Luca LaurentiSimona Sica

Abstract

The acronym POEMS refers to polyneuropathy, organomegaly, endocrinopathy, M protein, skin changes. This disease is progressive and weakening for patients and lead to death generally for neurological problem without therapy. We treated four patients affected by POEMS syndrome with front-line chemotherapy and autologous peripheral blood stem cell transplantation (aPBSCT). After a median follow-up of 40.5 months (range 12-52), all patients are alive with slow but progressive improvement in neurological disease, skin changes, performance status and without evidence of clonal plasmacytosis and organomegaly. In conclusion early diagnosis is crucial to obtain best response and improve clinical outcome.

References

Sep 18, 2002·Bone Marrow Transplantation·K S PeggsK Yong
Nov 24, 2005·Hematology·Angela Dispenzieri

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Citations

Dec 2, 2008·Nature Clinical Practice. Neurology·Alain CréangeAline Santin
Jul 10, 2012·Neurologia i neurochirurgia polska·Monika SójkaAndrzej Bogucki
Feb 13, 2013·British Journal of Haematology·Jian Li, Dao-bin Zhou
Jun 18, 2011·American Journal of Hematology·Angela Dispenzieri
Jul 19, 2012·American Journal of Hematology·Angela Dispenzieri
Feb 18, 2014·American Journal of Hematology·Angela Dispenzieri
Sep 4, 2015·American Journal of Hematology·Angela Dispenzieri
Oct 8, 2014·Muscle & Nerve·Divisha RahejaZachary Simmons
Jul 17, 2015·Saudi Journal of Kidney Diseases and Transplantation : an Official Publication of the Saudi Center for Organ Transplantation, Saudi Arabia·Karim ZouaghiFatma Ben Moussa
May 2, 2012·Blood·Angela Dispenzieri
Mar 31, 2015·Scottish Medical Journal·Yuanyuan LiuXiang Li
Jul 13, 2017·American Journal of Hematology·Angela Dispenzieri
Apr 24, 2019·American Journal of Hematology·Angela Dispenzieri
May 18, 2021·American Journal of Hematology·Angela Dispenzieri

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