Early diagnosis of adenovirus infection and treatment with cidofovir after bone marrow transplantation in children

Bone Marrow Transplantation
F LegrandE Vilmer

Abstract

Adenovirus infection remains an important cause of mortality after bone marrow transplantation (BMT). Currently no efficient antiviral treatment is known. Thus, testing new modalities of early diagnosis and treatment is a crucial objective. Adenovirus infection is defined by the combination of symptoms and the isolation of virus from the source of clinical symptoms. The involvement of two or more organs and the presence of virus in blood cultures define disseminated disease. Seven children with a median age of 7 years received bone marrow transplantation for leukemia. All received an unrelated graft without T cell depletion. Adenovirus was sought in blood, urine and biopsy specimens using PCR and culture. Analysis of biopsy specimens included systematic immunohistochemistry. Cidofovir treatment was initiated as soon as biopsy revealed the histopathological signs of adenovirus. Cidofovir was given at 5 mg/kg once weekly for 3 weeks then every 2 weeks. Six patients had diarrhoea and one patient had cystitis. Adenovirus infection and disseminated disease were diagnosed in four cases and three cases, respectively. In six cases, serotype A31 was isolated from gastrointestinal biopsy and in two cases serotypes B2 and C6 were detected...Continue Reading

References

Jul 1, 1992·Clinical Microbiology Reviews·J C Hierholzer
Feb 28, 1985·The New England Journal of Medicine·A F ShieldsJ D Meyers
Apr 1, 1994·The Journal of Infectious Diseases·P FlomenbergN Bunin
Mar 1, 1996·Journal of Clinical Microbiology·A H KiddJ C De Jong
Nov 14, 1997·American Journal of Respiratory and Critical Care Medicine·C MasloW Rozenbaum
Jan 9, 1998·Bone Marrow Transplantation·F E ChenM Peiris
Jun 13, 1998·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·S A HedderwickN M Clark
Oct 24, 1998·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·S DalapathyH N Madhavan
Mar 20, 1999·Bone Marrow Transplantation·G A HaleC C Patrick
Apr 8, 1999·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·P RibaudE Gluckman

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Citations

Jan 18, 2007·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Eiichi UchioShigeaki Ohno
Feb 11, 2011·Current Infectious Disease Reports·Anjali N Kunz, Martin Ottolini
Jun 4, 2008·Current Urology Reports·Darius A Paduch
May 30, 2002·Transplantation Proceedings·S S KaufmanT M Fishbein
Jun 22, 2002·Antiviral Research·Paul J HippenmeyerDavid W Griggs
Dec 18, 2001·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Kirsten St GeorgeCharles R Rinaldo
Nov 9, 2002·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·S M L WaughW F Carman
Feb 1, 2003·The Lancet Infectious Diseases·Tony WallsDelane Shingadia
May 16, 2006·Bone Marrow Transplantation·M Leruez-VilleS Blanche
Jul 9, 2002·British Journal of Haematology·Per Ljungman
Dec 18, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Marianne Leruez-VilleChristine Rouzioux
May 25, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·A C LankesterA C M Kroes
Nov 17, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·William J MullerRoger Giller
Jun 29, 2006·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Michael G Ison
Sep 21, 2007·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Veronique ErardMichael Boeckh
Mar 16, 2013·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Marius C FlorescuDiana F Florescu
Jul 20, 2002·Current Opinion in Infectious Diseases·Michael G Ison, Frederick G Hayden
Jan 2, 2003·The Pediatric Infectious Disease Journal·Annabel RectorMarc Van Ranst
Aug 31, 2006·The Pediatric Infectious Disease Journal·Marcela Hernández de MezervilleUpton Allen
Mar 24, 2005·Transplantation·David ZiringDouglas G Farmer
Jun 23, 2011·The Pediatric Infectious Disease Journal·Hammam GhanaiemDan Engelhard
Jul 22, 2004·Journal of Paediatrics and Child Health·M HatherillA Argent
Feb 25, 2005·Antimicrobial Agents and Chemotherapy·L NaesensErik De Clercq
Apr 11, 2008·Clinical Microbiology Reviews·W Garrett NicholsMichael Boeckh
Oct 16, 2008·Clinical Microbiology Reviews·Marcela Echavarría
Oct 9, 2003·Journal of Clinical Microbiology·Z GuR T Hayden
Oct 17, 2003·American Journal of Clinical Pathology·Teresa Tram N PhamLaura P Hale
Aug 4, 2012·Clinical Journal of the American Society of Nephrology : CJASN·Parmjeet Randhawa, Roslyn B Mannon
Mar 12, 2003·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·G Miflin, S E Kinsey
Feb 19, 2002·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·A C LankesterA C M Kroes
Feb 28, 2007·Leukemia & Lymphoma·Tobias FeuchtingerRupert Handgretinger
Oct 16, 2004·Expert Review of Anti-infective Therapy·Eric De Clercq
Oct 16, 2004·Expert Review of Anti-infective Therapy·W Garrett Nichols
Oct 16, 2004·Expert Review of Anti-infective Therapy·Mark R Schleiss, Michael A McVoy
Aug 19, 2015·Transplant Infectious Disease : an Official Journal of the Transplantation Society·L SwartlingE Sparrelid

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