Early diagnosis of deep vein thrombosis in female patients who undergo total knee arthroplasty with measurement of P-selectin activation

Journal of Vascular Surgery
Lin-Cheng YangTao-Chen Lee

Abstract

Deep vein thrombosis (DVT) remains a leading cause of postoperative morbidity and mortality in patients who undergo total knee arthroplasty (TKA). Although patients with previous thrombotic episodes are inherently at a higher risk for subsequent episodes of DVT, it remains difficult to predict such an occurrence and to make a diagnosis in early stages. One potentially useful assay that can be used in the determination of changes of coagulation among patients who undergo arthroplasty is platelet activation. The goal of this study was to establish a predictive value for DVT with measurement of P-selectin levels that could help in planning appropriate perioperative management strategies for patients at high risk for DVT. A total of 52 patients who underwent TKA with general anesthesia underwent contrast venography on the 5th postoperative day. Platelet activation before and after operation was measured with platelet surface expression of P-selectin with flow cytometry in these two groups of patients for TKA. None of the patients underwent any anticoagulation therapy. Nineteen of the 52 patients for TKA showed radiologic evidence of DVT, whereas 33 patients for TKA had no radiologic signs of DVT. There was no difference in platelet...Continue Reading

References

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Citations

May 20, 2011·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Eduardo RamacciottiThomas W Wakefield
Sep 20, 2005·Seminars in Vascular Surgery·Thomas W Wakefield, Peter K Henke
Aug 16, 2016·Annals of Vascular Surgery·Hidetoshi UchiyamaTatsuyuki Kawano
Nov 23, 2006·Clinical Orthopaedics and Related Research·M de JongR W Crawford
Dec 16, 2006·Medicina clínica·Marcial MartínezFrancisco Gabriel

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