Abstract
Delayed cerebral ischemia (DCI) after subarachnoid hemorrhage (SAH) is one of the main causes of neurologic deterioration. However, it frequently evades timely detection. Early identification and effective reversal may improve the clinical outcome. In this prospective study, we evaluate several serum inflammatory markers after aneurysmal SAH with regard to the occurrence of DCI. On days 1, 4, 7, 10, and 14 after SAH, leucocyte count, C-reactive protein, interleukin 6, E-selectin, matrix metallopeptidase 9, intercellular adhesion molecule 1, and leukemia inhibitory factor were assessed in patients' serum samples. Using a Cox regression model (SPSS 21.0), associations of baseline parameters, maximum and delta (maximum minus baseline) values with occurrence of DCI were evaluated. Considering the assessed parameters, leucocyte count (high baseline and delta values) matches most closely with occurrence of DCI. Although baseline levels of C-reactive protein are also associated with occurrence of DCI, neither maximum (only on a borderline level) nor delta levels do so. Our data analysis identified leucocyte count as the parameter most likely associated with occurrence of DCI. However, because of its lack of specificity leucocyte count...Continue Reading
References
Mar 1, 1987·Surgical Neurology·A SpalloneB Guidetti
Mar 1, 1997·Stroke; a Journal of Cerebral Circulation·C L Sudlow, C P Warlow
Aug 1, 1997·Journal of Neurosurgery·T MathiesenB Andersson
Dec 8, 1998·Acta neurochirurgica·K OsukaJ Yoshida
Mar 20, 2001·Journal of Neurology, Neurosurgery, and Psychiatry·K FassbenderM Hennerici
Jan 17, 2002·Journal of Neurosurgery·William J MackE Sander Connolly
Apr 18, 2003·Neurosurgery·Pawan S MinhasJohn D Pickard
Jun 21, 2003·Journal of Neurosurgery·Matthew J McGirtJohn R Lynch
Jun 26, 2003·Neurosurgery·Aaron S DumontKevin S Lee
Dec 22, 2005·Journal of Neurosurgical Anesthesiology·Ralf Dirk RothoerlAlexander Brawanski
May 13, 2006·Cerebrovascular Diseases·Ralf Dirk RothoerlAna-Luisa Pina
Apr 27, 2007·Neurosurgery·Beate SchochDietmar Stolke
May 1, 2007·Trends in Pharmacological Sciences·Jacob Hansen-SchwartzJohn H Zhang
May 20, 2008·Surgical Neurology·Yoshitaka KuboAkira Ogawa
May 5, 2009·Neurosurgical Focus·Kostas N FountasJoe Sam Robinson
Jul 2, 2010·Neurocritical Care·Alan K H TamR Loch Macdonald
Jul 3, 2010·Stroke; a Journal of Cerebral Circulation·Timour Al-KhindiTom A Schweizer
Aug 21, 2010·Neurocritical Care·Asita SarrafzadehPeter Vajkoczy
May 5, 2012·Stroke; a Journal of Cerebral Circulation·E Sander ConnollyUNKNOWN Council on Clinical Cardiology
Jun 27, 2012·Journal of Neurosurgical Anesthesiology·Young-Tae JeonHee-Pyoung Park
Sep 7, 2012·Journal of Neurointerventional Surgery·Catherine J McMahonPippa J Tyrrell
Dec 5, 2012·Neurosurgery·Carl MuroiEmanuela Keller
Dec 11, 2013·Nature Reviews. Neurology·R Loch Macdonald
May 9, 2014·Journal of the Neurological Sciences·Ana Rodríguez-RodríguezFrancisco Murillo-Cabezas
Aug 12, 2014·BioMed Research International·Brandon A MillerGustavo Pradilla
Sep 12, 2015·Clinical Neurology and Neurosurgery·Anke HölligHans Clusmann
Feb 24, 2016·World Neurosurgery·Anirudh SrinivasanSivashanmugam Dhandapani
Citations
Jan 10, 2018·Frontiers in Neurology·Anke HölligMark Coburn
Jan 20, 2019·Journal of Neurosurgery·Chen-Yu DingDe-Zhi Kang
Jul 11, 2019·Annals of Neurology·Matthew B BeversW Taylor Kimberly
Feb 29, 2020·International Journal of Molecular Sciences·Shafqat Rasul ChaudhrySajjad Muhammad
Mar 12, 2020·Stroke; a Journal of Cerebral Circulation·India A LissakEric S Rosenthal
Oct 25, 2017·Current Atherosclerosis Reports·Joseph R Geraghty, Fernando D Testai
Nov 8, 2017·Frontiers in Neurology·Devin W McBrideJohn H Zhang
Apr 10, 2019·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Aisha R SaandSherry H-Y Chou
Feb 7, 2020·Brain and Behavior·Chenyu DingJianjun Gu
Jan 8, 2021·Frontiers in Neurology·Susanna BacigaluppiGianluigi Zona
Jan 10, 2021·Scientific Reports·Sami RidwanMatthias Simon
Dec 30, 2020·World Neurosurgery·Xin ZhangAimin Li
Nov 30, 2020·Experimental Neurology· Zeyu Zhang Sheng Chen
Sep 30, 2020·Acta Neurologica Scandinavica·Sandra Bjerkne WennebergLinda Block
May 1, 2021·International Journal of Molecular Sciences·Matthias Simon, Alexander Grote
May 22, 2021·World Neurosurgery·Walid AlbannaGerrit Alexander Schubert
Aug 13, 2021·Frontiers in Neurology·Aaron M GusdonHuimahn Alex Choi
Aug 28, 2021·Neurosurgical Review·Davide Marco CrociSerge Marbacher