Jun 27, 2017

Early diagnosis of mild cognitive impairment and Alzheimer's disease based on salivary lactoferrin

Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring
Eva CarroGorka Orive

Abstract

The Alzheimer's disease (AD) process is likely initiated many years before clinical onset. Biomarkers of preclinical disease are critical for the development of disease-modifying or even preventative therapies. Current biomarkers for early disease, including cerebrospinal fluid tau and amyloid β (Aβ) levels, structural and functional magnetic resonance imaging, and the use of brain amyloid imaging, are limited because they are very invasive or expensive. Noninvasive biomarkers may be a more accessible alternative, but none can currently detect preclinical AD with the required sensitivity and specificity. Here, we show a novel, straight-forward, and noninvasive approach for assessment of early stages of cognitive decline. Salivary samples from cases of amnestic mild cognitive impairment (aMCI) and AD, and neurology controls were analyzed. We have discovered and validated a new single saliva biomarker, lactoferrin, which in our cross-sectional investigation perfectly discriminates clinically diagnosed aMCI and AD patients from a cognitively healthy control group. The accuracy for AD diagnosis shown by salivary lactoferrin was greater than that obtained from core cerebrospinal fluid (CSF) biomarkers, including total tau and CSF Aβ...Continue Reading

  • References3
  • Citations6

References

  • References3
  • Citations6

Citations

Mentioned in this Paper

Biological Markers
Diagnosis, Noninvasive
APP protein, human
Magnetic Resonance Imaging
Brain
Saliva - SpecimenType
Cerebrospinal Fluid
Alzheimer's Disease
Evaluation
Amyloid Deposition

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