PMID: 6966534Jun 1, 1980

Early diagnosis of mycosis fungoides and Sézary's syndrome by morphometric analysis of lymphoid cells in the skin

Cancer
C J MeijerC J Cornelisse

Abstract

Mycosis fungoides (MF) and Sézary's syndrome (SS) are cutaneous T-cell lymphomas characterized ultrastructurally by the presence of lymphoid cells with deep and narrow nuclear indentations (cerebriform mononuclear cells or CMC). Early diagnosis of MF and SS is difficult because in their early stages they often resemble various forms of chronic, benign skin lesions. By measuring the frequency distribution of a nuclear shape parameter (nuclear contour index or NCI) of lymphoid cells in skin infiltrates using computer assisted planimetry, we tried to classify suspect cases into the malignant and benign groups. From 12 patients with MF or SS (malignant group) and 11 patients with chronic, benign skin lesions (benign group) the frequency distribution of the NCI of the lymphoid cell population was measured. Nonlinear discriminant analysis selected the 70th and 25th percentile of the NCI distribution of the lymphoid cells in the skin infiltrates as parameters by which these patients could be classified correctly into the malignant or benign groups with a probability of over 95%. The predictive value of these parameters was tested on ten patients suspected of having cutaneous T-cell lymphomas. Three cases were classified as benign and ...Continue Reading

References

Jan 1, 1975·Archives of Dermatology·J A YeckleyG G Krueger
Apr 27, 1977·Archives of Dermatological Research·M Hagedorn, G Kiefer
Sep 1, 1976·Clinical and Experimental Dermatology·P D Samman
Oct 1, 1975·The Journal of Investigative Dermatology·A W van LeeuwenJ C de Man
Apr 11, 1976·Cancer·B N RobinowitzH H Roenigk
Aug 1, 1971·Archives of Dermatology·B A FlaxmanE J Van Scott
Aug 1, 1972·American Journal of Clinical Pathology·E R FisherH L Wechsler
Aug 16, 1973·The New England Journal of Medicine·J C BrouetM Seligmann
Jul 1, 1974·Journal of the National Cancer Institute·T L Litovitz, M A Lutzner
Oct 1, 1974·Cancer·H Rappaport, L B Thomas
Sep 1, 1970·Cancer·T R Brownlee, T M Murad
Jan 1, 1980·Pathology, Research and Practice·C J CornelisseK van den Broek

Citations

Jan 1, 1984·Archives of Dermatological Research·S C van der PutteJ A van Unnik
Jan 1, 1984·Virchows Archiv. A, Pathological Anatomy and Histopathology·K HelanderG Holmberg
Jan 1, 1987·Virchows Archiv. A, Pathological Anatomy and Histopathology·H Schultz, J Ersbøll
Jan 1, 1991·Electron Microscopy Reviews·R J SokolN T James
Mar 1, 1983·Journal of Clinical Pathology·P van der ValkC J Meijer
May 1, 1985·Journal of Clinical Pathology·P Olde KalterG B Snow
Apr 1, 1984·The Journal of Clinical Investigation·S E ShackneyJ W Parker
Jan 11, 1992·Ultrastructural Pathology·C M PayneC S Rangel
Jun 1, 1992·Pathology, Research and Practice·A MaioranaS Garbisa
Mar 1, 1986·Journal of the American Academy of Dermatology·S C van der PutteW A van Vloten
May 1, 1982·Journal of the American Academy of Dermatology·E M McMillanM A Everett
Sep 1, 1981·Journal of the American Academy of Dermatology·E M McMillanM A Everett
Feb 1, 1984·Journal of the American Academy of Dermatology·R J Barr
Jan 1, 1985·Journal of the American Academy of Dermatology·E M McMillan
Jul 1, 1982·Journal of the American Academy of Dermatology·B H Thiers
Jun 1, 1983·Journal of the American Academy of Dermatology·R M Mandojana, E B Helwig
May 1, 1996·Human Pathology·L D True
Jan 1, 1989·Computerized Medical Imaging and Graphics : the Official Journal of the Computerized Medical Imaging Society·D L McEachronL D True
Jun 1, 1986·European Journal of Cancer & Clinical Oncology·F M LarussaF Serri
Jan 1, 1982·Arthritis and Rheumatism·R M van SoesbergenW P van Beek
Feb 1, 1982·Journal of Cutaneous Pathology·R J BarrJ E Buck
May 1, 1985·Histopathology·E C OomsR W Veldhuizen
Apr 1, 1989·Pathology·S RoyC K Banerjee
Nov 1, 1990·Current Problems in Cancer·R T HoppeE A Abel
Feb 1, 1989·Journal of Cutaneous Pathology·E RiegerH Kerl
Jan 1, 1981·Clinical and Experimental Dermatology·S C van der Putte, J B van der Meer
Mar 1, 1981·The British Journal of Dermatology·E M van der LooC J Meijer
Jun 1, 1985·The British Journal of Dermatology·W A van VlotenE M Noordijk
Aug 1, 1982·The British Journal of Dermatology·L HammingaW A van Vloten
Jan 1, 1983·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·E de VriesA Cats
Jan 1, 1996·The British Journal of Dermatology·F HeuleT van Joost
Jan 1, 1988·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·R J SokolJ Wales
Oct 1, 1984·International Journal of Dermatology·N C McFadden
Jan 1, 1990·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·R J SokolJ Wales

Related Concepts

Brain
Cell Density
Cell Nucleus
Differential Diagnosis
DNA, Neoplasm
Mycosis Fungoides
Sezary Syndrome
Malignant Neoplasm of Skin
T-Lymphocyte

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Systemic Juvenile Idiopathic Arthritis

Systemic juvenile idiopathic arthritis is a rare rheumatic disease that affects children. Symptoms include joint pain, but also fevers and skin rashes. Here is the latest on this disease.

Chromatin Regulation and Circadian Clocks

The circadian clock plays an important role in regulating transcriptional dynamics through changes in chromatin folding and remodelling. Discover the latest research on Chromatin Regulation and Circadian Clocks here.

Central Pontine Myelinolysis

Central Pontine Myelinolysis is a neurologic disorder caused most frequently by rapid correction of hyponatremia and is characterized by demyelination that affects the central portion of the base of the pons. Here is the latest research on this disease.

Myocardial Stunning

Myocardial stunning is a mechanical dysfunction that persists after reperfusion of previously ischemic tissue in the absence of irreversible damage including myocardial necrosis. Here is the latest research.

Pontocerebellar Hypoplasia

Pontocerebellar hypoplasias are a group of neurodegenerative autosomal recessive disorders with prenatal onset, atrophy or hypoplasia of the cerebellum, hypoplasia of the ventral pons, microcephaly, variable neocortical atrophy and severe mental and motor impairments. Here is the latest research on pontocerebellar hypoplasia.

Cell Atlas Along the Gut-Brain Axis

Profiling cells along the gut-brain axis at the single cell level will provide unique information for each cell type, a three-dimensional map of how cell types work together to form tissues, and insights into how changes in the map underlie health and disease of the GI system and its crosstalk with the brain. Disocver the latest research on single cell analysis of the gut-brain axis here.

Chronic Traumatic Encephalopathy

Chronic Traumatic Encephalopathy (CTE) is a progressive degenerative disease that occurs in individuals that suffer repetitive brain trauma. Discover the latest research on traumatic encephalopathy here.