Early differential defects of insulin secretion and action in 19-year-old caucasian men who had low birth weight

Diabetes
C B JensenA A Vaag

Abstract

Several studies have linked low birth weight (LBW) and type 2 diabetes. We investigated hepatic and peripheral insulin action including intracellular glucose metabolism in 40 19-year-old men (20 LBW, 20 matched control subjects), using the hyperinsulinemic-euglycemic clamp technique at two physiological insulin levels (10 and 40 mU/m(2) per min), indirect calorimetry, and [3-(3)H]glucose. Insulin secretion was examined during an oral and intravenous glucose tolerance test. Fasting p-glucose was higher in the LBW group (5.6 +/- 0.1 vs. 5.4 +/- 0.1; P < 0.05). Basal plasma glycerol concentrations were significantly lower in the LBW group. Insulin-stimulated glycolytic flux was significantly reduced, and suppression of endogenous glucose production was enhanced in the LBW group. Nevertheless, basal and insulin-stimulated rates of whole-body peripheral glucose disposal, glucose oxidation, lipid oxidation, exogenous glucose storage, and nonoxidative glucose metabolism were similar in the two groups. Insulin secretion was reduced by 30% in the LBW group, when expressed relative to insulin sensitivity (disposition index = insulin secretion x insulin action). We propose that reduced insulin-stimulated glycolysis precedes overt insulin ...Continue Reading

References

Aug 12, 1976·The New England Journal of Medicine·G P RavelliM W Susser
May 1, 1992·Diabetologia·S RobinsonC Osmond
Jun 1, 1992·Journal of Epidemiology and Community Health·C M LawS J Simmonds
Oct 26, 1991·BMJ : British Medical Journal·C N HalesP D Winter
Apr 1, 1995·Diabetic Medicine : a Journal of the British Diabetic Association·C S YajnikD J Barker
May 1, 1995·Biochemical Society Transactions·M DesaiC N Hales
Jun 1, 1994·Diabetologia·D I PhillipsC Osmond
Nov 1, 1994·The American Journal of Physiology·B A Marshall, M M Mueckler
Oct 1, 1994·Archives of Disease in Childhood·A Lucas
Feb 1, 1994·Diabetologia·D I PhillipsC Osmond
Feb 1, 1993·The Journal of Clinical Investigation·S Del PratoR A DeFronzo
Mar 1, 1993·Diabetologia·K PhippsP M Clark
Jul 1, 1995·The Proceedings of the Nutrition Society·S DahriJ J Hoet
Jan 1, 1996·Metabolism: Clinical and Experimental·O Hother-NielsenH Beck-Nielsen
Apr 1, 1996·The American Journal of Physiology·S E OzanneC N Hales
Oct 1, 1996·The British Journal of Nutrition·M DesaiC N Hales
Dec 1, 1996·The American Journal of Physiology·S E OzanneG D Smith
May 1, 1997·Biological Reviews of the Cambridge Philosophical Society·M Desai, C N Hales
Feb 5, 1998·Lancet·A C RavelliO P Bleker
Mar 6, 1999·Annals of Internal Medicine·J W Rich-EdwardsJ E Manson

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Citations

Apr 25, 2012·Cell and Tissue Research·Linda A GalloMary E Wlodek
Aug 8, 2007·Reviews in Endocrine & Metabolic Disorders·Rebecca A Simmons
Sep 10, 2003·Best Practice & Research. Clinical Endocrinology & Metabolism·Henning Beck-NielsenMichael Gaster
Jul 8, 2011·The British Journal of Nutrition·Jacqueline M WallaceRaymond P Aitken
Nov 30, 2010·The Proceedings of the Nutrition Society·Rebecca Simmons
Oct 1, 2010·Journal of Developmental Origins of Health and Disease·H S KahnL H Lumey
Jun 1, 2012·Journal of Developmental Origins of Health and Disease·A K PortellaP P Silveira
Dec 1, 2012·Journal of Developmental Origins of Health and Disease·T D BrutsaertT B Gage
Apr 26, 2012·International Journal of Obesity : Journal of the International Association for the Study of Obesity·S CianfaraniA Pietrobelli
Dec 7, 2007·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Allan Vaag, Søren S Lund
Apr 7, 2007·Pediatric Research·Wayne S CutfieldIan M Morison
Oct 14, 2011·The Journal of Clinical Endocrinology and Metabolism·Sylvie Dufour, Kitt Falk Petersen
Jan 18, 2012·European Journal of Endocrinology·Nihal ThomasIb C Bygbjerg
Mar 13, 2010·The Journal of Endocrinology·Alice S GreenSean W Limesand
Jul 28, 2012·Indian Journal of Endocrinology and Metabolism·Vivek Mathew, S Vageesh Ayyar
Aug 12, 2006·Scandinavian Journal of Clinical and Laboratory Investigation·P R HillestrømH E Poulsen
Sep 18, 2012·Best Practice & Research. Clinical Endocrinology & Metabolism·Rebecca A Simmons
Jun 9, 2009·Pediatric Clinics of North America·Rebecca A Simmons
Sep 1, 2007·The Journal of Physiology·Julie A OwensAbigail L Fowden
Jun 10, 2008·Best Practice & Research. Clinical Endocrinology & Metabolism·Jacques Beltrand, Claire Lévy-Marchal
Nov 23, 2005·Pediatric Clinics of North America·Neslihan GungorSilva Arslanian
Nov 29, 2005·Endocrinology and Metabolism Clinics of North America·Rebecca Simmons
Sep 4, 2003·American Journal of Human Biology : the Official Journal of the Human Biology Council·Benjamin CampbellSusan F Lipson
Apr 25, 2009·Diabetic Medicine : a Journal of the British Diabetic Association·K FaerchK Borch-Johnsen
Jul 16, 2010·Pediatrics International : Official Journal of the Japan Pediatric Society·Jung Sub LimSei Won Yang

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