Early differential expression of oncostatin M in obstructive nephropathy.

Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research
Wafa M ElbjeiramiC Wayne Smith

Abstract

Interstitial fibrosis plays a major role in progression of renal diseases. Oncostatin M (OSM) is a cytokine that regulates cell survival, differentiation, and proliferation. Renal tissue from patients with chronic obstructive nephropathy was examined for OSM expression. The elevated levels in diseased human kidneys suggested possible correlation between OSM level and kidney tissue fibrosis. Indeed, unilateral ureteral obstruction (UUO), a model of renal fibrosis, increased OSM and OSM receptor (OSM-R) expression in a time-dependent manner within hours following UUO. In vitro, OSM overexpression in tubular epithelial cells (TECs) resulted in epithelial-myofibroblast transdifferentiation. cDNA microarray technology identified up-regulated expression of immune modulators in obstructed compared with sham-operated kidneys. In vitro, OSM treatment up-regulated CC chemokine ligand CCL7, and CXC chemokine ligand (CXCL)-14 mRNA in kidney fibroblasts. In vivo, treatment of UUO mice with neutralizing anti-OSM antibody decreased renal chemokines expression. In conclusion, OSM is up-regulated in kidney tissue early after urinary obstruction. Therefore, OSM might play an important role in initiation of renal fibrogenesis, possibly by inducin...Continue Reading

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Citations

Jul 22, 2011·American Journal of Physiology. Cell Physiology·Wafa M ElbjeiramiC Wayne Smith
Jan 2, 2014·ISRN Inflammation·Carl D Richards
Nov 13, 2013·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Qingjuan LiuHuijun Duan
Mar 16, 2019·Biomedicines·Aaron L MagnoVance B Matthews
Jun 20, 2017·Mediators of Inflammation·Qingjuan LiuShuxia Liu
Oct 15, 2020·Scientific Reports·Shimpei YamashitaYoshihiro Morikawa

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BETA
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transfection
transfections
biopsy
biopsies

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DAVID

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