Early diphtheria-tetanus-pertussis vaccination associated with higher female mortality and no difference in male mortality in a cohort of low birthweight children: an observational study within a randomised trial.

Archives of Disease in Childhood
Peter AabyChristine Stabell Benn

Abstract

Studies from low-income countries have suggested that diphtheria-tetanus-pertussis (DTP) vaccine provided after Bacille Calmette-Guerin (BCG) vaccination may have a negative effect on female survival. The authors examined the effect of DTP in a cohort of low birthweight (LBW) infants. 2320 LBW newborns were visited at 2, 6 and 12 months of age to assess nutritional and vaccination status. The authors examined survival until the 6-month visit for children who were DTP vaccinated and DTP unvaccinated at the 2-month visit. Two-thirds of the children had received DTP at 2 months and 50 deaths occurred between the 2-month and 6-month visits. DTP vaccinated children had a better anthropometric status for all indices than DTP unvaccinated children. Small mid-upper arm circumference (MUAC) was the strongest predictor of mortality. The death rate ratio (DRR) for DTP vaccinated versus DTP unvaccinated children differed significantly for girls (DRR 2.45; 95% CI 0.93 to 6.45) and boys (DRR 0.53; 95% CI 0.23 to 1.20) (p=0.018, homogeneity test). Adjusting for MUAC, the overall effect for DTP vaccinated children was 2.62 (95% CI 1.34 to 5.09); DRR was 5.68 (95% CI 1.83 to 17.7) for girls and 1.29 (95% CI 0.56 to 2.97) for boys (p=0.023, homo...Continue Reading

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Citations

Jun 27, 2014·The Journal of Infectious Diseases·Maximilian Muenchhoff, Philip J R Goulder
Dec 12, 2012·Australian and New Zealand Journal of Public Health·Frank Shann
Apr 5, 2014·Vaccine·Ane Bærent FiskerPeter Aaby
Aug 29, 2014·The Journal of Infectious Diseases·Maximilian Muenchhoff, Philip Goulder
Jan 13, 2015·Transactions of the Royal Society of Tropical Medicine and Hygiene·Peter AabyJean-François Trape
Jun 9, 2016·Bulletin of the World Health Organization·Maureen O'LearyKaren Edmond
Oct 30, 2016·Transactions of the Royal Society of Tropical Medicine and Hygiene·Peter AabyJean-François Trape
Mar 19, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Clara Clipet-JensenK Zaman
Jun 24, 2020·Human Vaccines & Immunotherapeutics·Syed Manzoor Ahmed HanifiAbbas Bhuiya
Feb 18, 2020·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·Bastiaan A BlokMihai G Netea
Nov 20, 2016·International Journal of Epidemiology·Christine Stabell Benn, Signe Sørup
May 15, 2013·Scandinavian Journal of Clinical and Laboratory Investigation·Nikolaj W ØrntoftJane Agergaard
Oct 19, 2016·The Pediatric Infectious Disease Journal·Peter AabyChristine S Benn

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NCT00146302
NCT00168610

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