Early discriminatory diagnosis of dementia with Lewy bodies. The emerging role of CSF and imaging biomarkers

Dementia and Geriatric Cognitive Disorders
D AarslandC Ballard

Abstract

The clinical diagnostic criteria for dementia with Lewy bodies (DLB) have a low sensitivity, and there are no generally accepted biomarkers to distinguish DLB from other dementias. Our aim was to identify biomarkers that may differentiate DLB from Alzheimer's disease (AD). We performed a systematic literature search for studies of EEG, imaging techniques and genetic and CSF markers that provide sensitivity and specificity in the identification of DLB. The best evidence was for scintigraphy of the striatal dopamine transporter system using FP-CIT SPECT. Several small scintigraphy studies of cardiovascular autonomic function using metaiodobenzylguanidine SPECT have reported promising results. Studies exploring innovative techniques based on CSF have reported interesting findings for the combination of amyloid beta (abeta) isoforms as well as alpha-synuclein, and there are interesting results emerging from preliminary studies applying proteomic techniques. Data from studies using structural MRI, perfusion SPECT, genetics and EEG studies show differences between DLB and AD but only at a group level. Several potential biomarkers for the differential diagnosis of probable DLB and AD have shown good diagnostic accuracy in the research...Continue Reading

References

Sep 19, 1992·BMJ : British Medical Journal·I McKeithE Perry
Nov 1, 1991·Archives of Neurology·M RichardsY Stern
Oct 1, 1990·Neurology·H A CrystalL I Wolfson
Mar 20, 1999·Journal of Neurology, Neurosurgery, and Psychiatry·R C BrielA F Fairbairn
Apr 24, 1999·Neurology·R BarberJ T O'Brien
Feb 5, 2000·Acta Neurologica Scandinavica·P A BarberD Neary
Jun 1, 2000·Movement Disorders : Official Journal of the Movement Disorder Society·T S BenamerV Ries
Oct 25, 2000·Dementia and Geriatric Cognitive Disorders·M P WalkerC G Ballard
Jun 1, 2001·Journal of Neurology, Neurosurgery, and Psychiatry·H WatanabeG Sobue
Jul 18, 2002·Journal of Neurology, Neurosurgery, and Psychiatry·Z WalkerC L E Katona
Nov 2, 2002·Dementia and Geriatric Cognitive Disorders·Andrew B SingletonChristopher M Morris
Jan 28, 2003·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·S CalzettiD Mancia
Jul 10, 2003·Archives of Gerontology and Geriatrics·Elisabet LondosLars Gustafson
Jul 24, 2003·Journal of Neurology, Neurosurgery, and Psychiatry·S EngelborghsP P De Deyn
Sep 17, 2003·Archives of Neurology·Estrella Gómez-TortosaTeodoro del Ser
Dec 25, 2003·Lancet Neurology·Ian McKeithUNKNOWN International Psychogeriatric Association Expert Meeting on DLB
Jul 6, 2004·Annals of Neurology·Kevin St P McNaughtC Warren Olanow
Jul 17, 2004·Neuroreport·Christian BrenneisWerner Poewe
Jan 8, 2005·Dementia and Geriatric Cognitive Disorders·Brit MollenhauerMarkus Otto
Jan 13, 2005·Movement Disorders : Official Journal of the Movement Disorder Society·Jörg SpiegelCarl-Martin Kirsch
Apr 16, 2005·Dementia and Geriatric Cognitive Disorders·Soichiro ShimizuKimihiko Abe
May 14, 2005·The Journal of Clinical Psychiatry·Dag AarslandClive G Ballard
Jun 25, 2005·Brain : a Journal of Neurology·Debra A FleischmanDavid A Bennett
Jul 16, 2005·Journal of the Neurological Sciences·Toru KaiKenji Nakashima

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Citations

May 25, 2012·Journal of Neural Transmission·Alessandro StefaniAlessandro Martorana
Mar 12, 2010·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Giorgio TregliaGiorgio Fagioli
Aug 28, 2012·Dementia and Geriatric Cognitive Disorders·Nicole ChowLiana G Apostolova
Nov 26, 2013·Biomarkers in Medicine·Katrin Beyer
May 28, 2011·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·John N CavinessThomas G Beach
Apr 22, 2011·Neurobiology of Aging·Gregory A JichaPeter T Nelson
Nov 28, 2012·Revista española de medicina nuclear e imagen molecular·V CamachoI Carrió
Jan 31, 2015·The Cochrane Database of Systematic Reviews·Jenny McCleeryChris Hyde
Apr 1, 2018·Evidence-based Mental Health·Ajenthan Surendranathan, John Tiernan O'Brien
Jun 5, 2010·Brain Pathology·Min ShiJing Zhang
Dec 13, 2019·Journal of the International Neuropsychological Society : JINS·Joanna CiafonePeter Gallagher
Apr 12, 2011·Movement Disorders : Official Journal of the Movement Disorder Society·Alisha E KingDonald R Royall
Oct 22, 2008·Neurobiology of Disease·Min ShiJing Zhang
Jul 17, 2019·Dementia and Geriatric Cognitive Disorders·George P ParaskevasElisabeth Kapaki

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