PMID: 15383560Sep 24, 2004Paper

Early divergence of Fc epsilon receptor I signals for receptor up-regulation and internalization from degranulation, cytokine production, and survival

The Journal of Immunology : Official Journal of the American Association of Immunologists
J KitauraT Kawakami

Abstract

Mast cells play a critical role in IgE-dependent immediate hypersensitivity. Monomeric IgE binding to its high affinity receptor (FcepsilonRI) results in a number of biological outcomes in mouse mast cells, including increased surface expression of FcepsilonRI and enhanced survival. IgE molecules display heterogeneity in inducing cytokine production; highly cytokinergic IgEs cause extensive FcepsilonRI aggregation, leading to potent enhancement of survival and other activation events, whereas poorly cytokinergic IgEs can do so less efficiently. In this study, we demonstrate that IgE-induced receptor up-regulation is not sensitive to monovalent hapten, which can prevent receptor aggregation induced by IgE, whereas other activation events such as receptor internalization, degranulation, IL-6 production, and survival are sensitive to monovalent hapten. IgE-induced receptor up-regulation is also unique in that no Src family kinases, Syk, or Btk are required for it. By contrast, highly cytokinergic IgE-induced receptor internalization is dependent on Lyn, but not other Src family kinases, Syk, or Btk, whereas degranulation, IL-6 production, and survival require Syk. Weak to moderate stimulation with IgE plus anti-IgE or IgE plus Ag ...Continue Reading

References

Jul 1, 1978·The Journal of Clinical Investigation·F J MalveauxL M Lichtenstein
Mar 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·K FuruichiC Isersky
Sep 1, 1995·Immunity·W N KhanL A Herzenberg
Mar 3, 1999·Proceedings of the National Academy of Sciences of the United States of America·Y KawakamiT Kawakami
Jun 8, 1999·Annual Review of Immunology·J P Kinet
Dec 23, 1999·The New England Journal of Medicine·H MilgromW J Metzger
Feb 13, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·H MaR L Geahlen
Jun 23, 2001·Immunity·K AsaiT Kawakami
Jul 24, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·T A BorkowskiJ P Kinet
Sep 7, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·S KuboH Karasuyama
Jun 29, 2002·Nature Immunology·Valentino ParraviciniJuan Rivera
Jul 18, 2002·The Journal of Experimental Medicine·Satoshi TanakaAtsushi Ichikawa
Oct 3, 2002·Nature Reviews. Immunology·Toshiaki Kawakami, Stephen J Galli
Mar 15, 2003·The New England Journal of Medicine·Donald Y M LeungUNKNOWN Avon Longitudinal Study of Parents and Children Study Team
Oct 22, 2003·Proceedings of the National Academy of Sciences of the United States of America·Jiro KitauraToshiaki Kawakami
Feb 7, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Daiju SakuraiTakashi Saito

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Citations

Sep 24, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Toshiaki Kawakami, Jiro Kitaura
Jul 15, 2005·Annals of the New York Academy of Sciences·Donald Macglashan
Aug 11, 2006·International Archives of Allergy and Immunology·Zou XiangGunnar Nilsson
May 15, 2007·Immunological Reviews·Odile Malbec, Marc Daëron
Jun 21, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Wai-Hang Leung, Silvia Bolland
May 15, 2008·Journal of Leukocyte Biology·Jun-ichi KashiwakuraToshiaki Kawakami
Aug 16, 2017·Scientific Reports·Heather J BaxHannah J Gould
Apr 11, 2019·Science Signaling·Soichiro YoshikawaHajime Karasuyama
Jul 5, 2007·Journal of Leukocyte Biology·Donald W MacGlashan
Nov 8, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Wenbin XiaoToshiaki Kawakami
Jan 31, 2009·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·A A Horner, T Kawakami
Apr 18, 2007·Nature Reviews. Immunology·Stefan Kraft, Jean-Pierre Kinet
Jul 14, 2009·International Immunology·Nimita H FifadaraSanta Jeremy Ono
May 15, 2007·Immunologic Research·Ming ZhangDevendra K Agrawal
Apr 22, 2005·Current Allergy and Asthma Reports·Paul J Bryce, Hans C Oettgen
Sep 5, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Laura M SlyGerald Krystal
Apr 9, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Reinhard Schweitzer-Stenner, Israel Pecht
Jul 14, 2010·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Jaciel Medina-TamayoClaudia González-Espinosa
Mar 21, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Maria EkoffGunnar Nilsson
Dec 2, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Michael PoderyckiToshiaki Kawakami
Mar 17, 2015·PloS One·Darrell PillingRichard H Gomer
May 2, 2017·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Jun-Ichi KashiwakuraToshiaki Kawakami
Apr 9, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jiro KitauraToshiaki Kawakami
Jun 5, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Archana S Iyer, Avery August
Aug 1, 2009·Molecular Biology Reports·Chenxiong LiuYaojiong Wu
May 23, 2012·Blood·Jan FricPaola Ricciardi-Castagnoli
Nov 3, 2005·Expert Opinion on Emerging Drugs·Giorgio Ciprandi, Giovanni Passalacqua
Nov 17, 2009·Biochemical and Biophysical Research Communications·Hiroshi TakenakaKo Okumura
Jul 3, 2013·The Journal of Allergy and Clinical Immunology·Tatsuya OkaStephen J Galli
Dec 7, 2020·Allergology International : Official Journal of the Japanese Society of Allergology·Jun-Ichi KashiwakuraTadashi Matsuda
Aug 28, 2021·Cells·Satoshi Tanaka, Kazuyuki Furuta

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