PMID: 8939468Oct 25, 1996Paper

Early effect of ApoE-epsilon 4 allele on cognitive results in a group of highly performing subjects: the EVA study. Etude sur le Vieillissement Artériel

Neuroscience Letters
C BerrA Alpérovitch

Abstract

We examined the association between apolipoprotein E (ApoE) epsilon 4 allele and cognitive performances in a population sample of 1174 high functioning volunteers aged 59-71 years. The neuropsychological battery included the Mini Mental State Examination (MMSE) and nine tests assessing visual attention, verbal memory, visual processing, logical reasoning, psychomotor rapidity, visual memory, auditory attention and verbal fluency. The ratio of genotypes with zero, one or two epsilon 4 alleles was 70.6%, 21.4% and 1.9%, respectively. The epsilon 4 allele was significantly associated with lower scores for visual attention, psychomotor rapidity and MMSE. In the best performer subgroup (MMSE score above 25, n = 1028), all relationships persisted. Our findings demonstrate that the ApoE-epsilon 4 allele is early associated with low normal cognitive performances in areas which are not specifically affected at the subclinical onset of dementia.

References

Jan 1, 1988·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·J DavignonC F Sing
Jul 1, 1995·Psychological Medicine·C BrayneD W O'Connor
May 26, 1995·Neuroscience Letters·E L HelkalaP Riekkinen
Nov 8, 1994·Proceedings of the National Academy of Sciences of the United States of America·W J StrittmatterA D Roses
Nov 5, 1994·BMJ : British Medical Journal·E J FeskensD Kromhout
May 1, 1994·Nature Genetics·C M van DuijnC Van Broeckhoven
Sep 18, 1993·Lancet·J PoirierS Gauthier
Nov 1, 1993·Annals of Neurology·R MayeuxH Ginsberg
Jul 1, 1996·Annals of Neurology·B T HymanR Wallace
Dec 18, 1995·American Journal of Medical Genetics·S M AlbertR Mayeux

❮ Previous
Next ❯

Citations

Feb 1, 2006·Irish Journal of Medical Science·R Salerno-KennedyK D Cashman
Oct 8, 1999·Clinica Chimica Acta; International Journal of Clinical Chemistry·J DavignonL Bernier
May 19, 2004·Journal of the International Neuropsychological Society : JINS·James A LevyTrey Sunderland
Sep 12, 2006·Journal of the International Neuropsychological Society : JINS·Elizabeth W TwamleyMark W Bondi
Dec 9, 2004·Psychology and Aging·Brent J SmallLars Bäckman
May 4, 2000·The Journals of Gerontology. Series B, Psychological Sciences and Social Sciences·K P RileyN Nanayakkara
Sep 24, 1999·Journal of Epidemiology and Community Health·S DanetC Berr
Apr 13, 2002·Neuropsychology·Raja ParasuramanTrey Sunderland
Dec 10, 2002·Neurobiology of Aging·Stephen R Robinson, Glenda M Bishop
Jun 13, 2003·Journal of Geriatric Psychiatry and Neurology·Linda M ErcoliGary W Small
Dec 18, 1998·AACN Clinical Issues·M E Kerr, M Kraus
Sep 18, 2001·Journal of the American Geriatrics Society·G G FillenbaumL J Launer
Dec 20, 2000·American Journal of Medical Genetics·J D FloryM F Muldoon
Jan 31, 2003·Annals of Neurology·Carole DufouilChristophe Tzourio
Oct 19, 2000·Journal of the American Geriatrics Society·C BerrA Alpérovitch
Mar 29, 2003·The American Journal of Clinical Nutrition·Barbara HeudeUNKNOWN EVA Study
Feb 13, 2001·European Journal of Pharmacology·F Richard, P Amouyel
Jun 18, 2002·Ageing Research Reviews·Jonathan D Smith
Feb 3, 2005·Neurobiology of Disease·Chunsheng WangPatrick M Sullivan

❮ Previous
Next ❯

Related Concepts

Related Feeds

Alzheimer's Disease: APOE

Apolipoprotein E (APOE) polymorphic alleles are major genetic risk factors for Alzheimer's disease. Discover the latest research on APOE and other genetic determinants of Alzheimer's disease here.

ApoE Phenotypes

Apolipoprotein E (APOE) is a protein involved in fat metabolism and associated with the pathogenesis of Alzheimer's disease and cardiovascular disease. Here is the latest research on APOE phenotypes.