Early effector maturation of naïve human CD8+ T cells requires mitochondrial biogenesis

European Journal of Immunology
Marco FischerChristoph Hess

Abstract

The role of mitochondrial biogenesis during naïve to effector differentiation of CD8+ T cells remains ill explored. In this study, we describe a critical role for early mitochondrial biogenesis in supporting cytokine production of nascent activated human naïve CD8+ T cells. Specifically, we found that prior to the first round of cell division activated naïve CD8+ T cells rapidly increase mitochondrial mass, mitochondrial respiration, and mitochondrial reactive oxygen species (mROS) generation, which were all inter-linked and important for CD8+ T cell effector maturation. Inhibition of early mitochondrial biogenesis diminished mROS dependent IL-2 production - as well as subsequent IL-2 dependent TNF, IFN-γ, perforin, and granzyme B production. Together, these findings point to the importance of mitochondrial biogenesis during early effector maturation of CD8+ T cells.

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Citations

Aug 29, 2019·International Journal of Molecular Sciences·Anna C Beielstein, Christian P Pallasch
Sep 2, 2020·Nature Biotechnology·Felix J HartmannSean C Bendall
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May 16, 2021·Applied Microbiology and Biotechnology·Zhepei XieHaibo Cai
Jun 24, 2021·Proceedings of the National Academy of Sciences of the United States of America·David O'SullivanErika L Pearce
Oct 15, 2021·Science·Miriam LisciGillian M Griffiths

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