Early Effects of a Low Fat, Fructose-Rich Diet on Liver Metabolism, Insulin Signaling, and Oxidative Stress in Young and Adult Rats

Frontiers in Physiology
Raffaella CrescenzoSusanna Iossa

Abstract

The increase in the use of refined food, which is rich in fructose, is of particular concern in children and adolescents, since the total caloric intake and the prevalence of metabolic syndrome are increasing continuously in these populations. Nevertheless, the effects of high fructose diet have been mostly investigated in adults, by focusing on the effect of a long-term fructose intake. Notably, some reports evidenced that even short-term fructose intake exerts detrimental effects on metabolism. Therefore, the aim of this study was to compare the metabolic changes induced by the fructose-rich diet in rats of different age, i.e., young (30 days old) and adult (90 days old) rats. The fructose-rich diet increased whole body lipid content in adult, but not in young rats. The analysis of liver markers of inflammation suggests that different mechanisms depending on the age might be activated after the fructose-rich diet. In fact, a pro-inflammatory gene-expression analysis showed just a minor activation of macrophages in young rats compared to adult rats, while other markers of low-grade metabolic inflammation (TNF-alpha, myeloperoxidase, lipocalin, haptoglobin) significantly increased. Inflammation was associated with oxidative dam...Continue Reading

References

Apr 1, 1974·Analytical Biochemistry·K L Roehrig, J B Allred
Jan 1, 1984·Methods in Enzymology·L Flohé, F Otting
Dec 31, 2003·Trends in Immunology·Paresh DandonaArindam Bandyopadhyay
Jul 11, 2006·The Journal of Clinical Investigation·Steven E ShoelsonAllison B Goldfine
Jan 5, 2010·Metabolism: Clinical and Experimental·Raffaella CrescenzoSusanna Iossa
Jan 21, 2010·Physiological Reviews·Luc Tappy, Kim-Anne Lê
Nov 17, 2011·The British Journal of Nutrition·Raffaella CrescenzoSusanna Iossa
Jan 10, 2012·Pediatric Annals·Andrew A Bremer, Robert H Lustig
Feb 15, 2012·Journal of Visualized Experiments : JoVE·Janice J KimWaliul I Khan
Feb 22, 2012·Pediatrics·Andrew A BremerRobert H Lustig
Jun 13, 2012·The International Journal of Developmental Biology·Margherita TussellinoRosa Carotenuto
Jul 17, 2012·Clinics and Research in Hepatology and Gastroenterology·Luc Tappy, Kim-Anne Lê
Oct 23, 2012·Biochimica Et Biophysica Acta·María C CastroFlavio Francini
Dec 25, 2012·Journal of the Academy of Nutrition and Dietetics·Christopher N FordBarry M Popkin
Feb 22, 2013·Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association·T AuguetC Richart
Apr 30, 2013·Pediatric Obesity·G A Bray, B M Popkin
May 31, 2013·The American Journal of Clinical Nutrition·Gina Leslie AmbrosiniSusan Ann Jebb
Jul 19, 2013·The Journal of Clinical Investigation·Joanna M WarszawskaSylvia Knapp
Dec 24, 2013·Biochimica Et Biophysica Acta·María C CastroMaría L Massa
Mar 4, 2014·World Journal of Gastroenterology : WJG·Salamah Mohammad AlwahshFrank Christian Schultze
Jun 1, 2014·Free Radical Biology & Medicine·Brian E Sansbury, Bradford G Hill
Jan 13, 2015·American Journal of Physiology. Gastrointestinal and Liver Physiology·Ryan D SheldonR Scott Rector
Mar 6, 2015·Biological Reviews of the Cambridge Philosophical Society·Francis W B Sanders, Julian L Griffin
Jul 24, 2015·Current Opinion in Clinical Nutrition and Metabolic Care·Ran Jin, Miriam B Vos
Sep 29, 2015·Trends in Endocrinology and Metabolism : TEM·Bhagirath Chaurasia, Scott A Summers
Mar 24, 2016·International Journal of Obesity : Journal of the International Association for the Study of Obesity·V C Campos, L Tappy
Jun 24, 2016·Endocrine Reviews·Margherita MaffeiFerruccio Santini
Oct 22, 2016·The Journal of Nutritional Biochemistry·Kaitlin MockJanet C Tou
Jan 11, 2017·Molecular Psychiatry·S S KangJ D Fryer
Jan 31, 2017·International Journal of Molecular Sciences·Salamah M AlwahshGiuliano Ramadori
Mar 25, 2017·Nutrients·Federica CioffiSusanna Iossa

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Citations

Mar 20, 2020·Journal of Developmental Origins of Health and Disease·Nyasha C MukonowenzouKennedy H Erlwanger
Nov 19, 2019·Frontiers in Genetics·Ruixue HouV Saroja Voruganti
Sep 30, 2020·Toxicological Sciences : an Official Journal of the Society of Toxicology·Marisa PfohlAngela L Slitt
Dec 31, 2020·Nutrients·Maria Stefania SpagnuoloLuisa Cigliano
Sep 11, 2021·Journal of Developmental Origins of Health and Disease·Marina Lummertz MagenisVanessa Moraes de Andrade

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Methods Mentioned

BETA
ELISA
enzyme linked immunosorbent assay
PCR
electron microscopy
electrophoresis

Software Mentioned

Un
ImageJ
Scan
GraphPad Prism
- It gel

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