Early effects of duloxetine on emotion recognition in healthy volunteers

Journal of Psychopharmacology
Susan BamfordMatthew Garner

Abstract

The serotonin-noradrenaline reuptake inhibitor (SNRI) duloxetine is an effective treatment for major depression and generalised anxiety disorder. Neuropsychological models of antidepressant drug action suggest therapeutic effects might be mediated by the early correction of maladaptive biases in emotion processing, including the recognition of emotional expressions. Sub-chronic administration of duloxetine (for two weeks) produces adaptive changes in neural circuitry implicated in emotion processing; however, its effects on emotional expression recognition are unknown. Forty healthy participants were randomised to receive either 14 days of duloxetine (60 mg/day, titrated from 30 mg after three days) or matched placebo (with sham titration) in a double-blind, between-groups, repeated-measures design. On day 0 and day 14 participants completed a computerised emotional expression recognition task that measured sensitivity to the six primary emotions. Thirty-eight participants (19 per group) completed their course of tablets and were included in the analysis. Results provide evidence that duloxetine, compared to placebo, may reduce the accurate recognition of sadness. Drug effects were driven by changes in participants' ability to ...Continue Reading

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Citations

Feb 6, 2019·Journal of Psychopharmacology·Jasmine N KhoujaMarcus R Munafò
Jun 3, 2017·Royal Society Open Science·Angela S AttwoodMarcus R Munafò
May 30, 2020·Journal of Psychopharmacology·Andrew Pr EastwoodAngela S Attwood
Feb 6, 2017·Social Cognitive and Affective Neuroscience·Camilla L NordJonathan P Roiser
Aug 29, 2018·Nature Communications·G Bragi WaltersKari Stefansson

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