Early effects of irradiation on [(123)I]-IMT and [(18)F]-FDG uptake in rat C6 glioma cells

Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]
Burkhard RiemannOtmar Schober

Abstract

Single-photon emission computed tomography (SPECT) using 3-[(123)I]-iodo-L-alpha-methyltyrosine ([(123)I]-IMT) and positron emission tomography (PET) using 2-[(18)F]-fluoro-2-deoxy-D-glucose ([(18)F]-FDG) are valuable tools for the distinction between viable tumor and radionecrosis in patients receiving radiotherapy for high-grade gliomas. However, to date, little is known about the early effects of radiation on [(123)I]-IMT and [(18)F]-FDG uptake in gliomas. To determine the early effects of irradiation on [(123)I]-IMT and [(18)F]-FDG uptake in gliomas, in vitro studies were performed using rat C6 glioma cells. The glioma cells were irradiated with 20 Gy which is a common dose applied to patients receiving intraoperative radiotherapy. Subsequently, the early kinetics of [(123)I]-IMT and [(18)F]-FDG uptake in glioma cells were monitored for 3 days. Micromorphometric examinations of the irradiated glioma cells revealed that about 25% of the viable cells transformed into giant cells. [(123)I]-IMT uptake per 10(5) viable glioma cells was unchanged on the 1st day post irradiation, but showed a significant increase on the 2nd and 3rd day following radiotherapy (p < 0.01). In addition, there was a moderate increase in [(18)F]- FDG ac...Continue Reading

Citations

Dec 24, 2004·European Journal of Nuclear Medicine and Molecular Imaging·Burkhard Riemann, Otmar Schober
Sep 29, 2007·International Journal of Radiation Oncology, Biology, Physics·Pawinee MahasittiwatHirohiko Tsujii
Jan 29, 2011·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Birgit MellerJohannes Meller
Nov 10, 2010·PloS One·Jaime R MerchanTheodore J Lampidis
Apr 27, 2011·Journal of Internal Medicine·F JoshiJ H F Rudd

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