Early effects of parathyroidectomy on erythropoietin production in secondary hyperparathyroidism

American Journal of Surgery
C YasunagaT Goya

Abstract

Secondary hyperparathyroidism (2-HPT) has an adverse effect on renal anemia and may cause a hyporesponsiveness to recombinant human erythropoietin (rHuEpo) in patients with chronic renal failure. The early effects of parathyroidectomy (PTx) on renal anemia, erythropoietin production, and nutritional state were examined. Twenty-nine patients under hemodialysis therapy received a PTx for 2-HPT. They were prospectively studied regarding hematological parameters, rHuEpo use, plasma erythropoietin levels, and nutritional condition until 12 months after PTx. The hemoglobin level showed a significant increase from 3 months after PTx (10.2% +/- 1.5% to 11.2% +/- 1.3%; P <0.01), associated with a consistent increase of the reticulocyte count. These changes lasted until 12 months after PTx. The plasma erythropoietin level showed a gradual increase of up to about 5 times the level of the preoperative value, until 12 months after PTx (22.6 +/- 10.1 to 106.3 +/- 112.1 mU/mL; P <0.001). The weekly dose of rHuEpo administration decreased after 3 months. The serum levels of albumin and total protein also significantly and gradually improved until 12 months after PTx. PTx caused a significant early improvement in renal anemia in patients with s...Continue Reading

References

Aug 1, 1979·Archives of Internal Medicine·G L Barbour
Dec 1, 1976·The American Journal of Digestive Diseases·T N ReismanA I Rogers
Jan 1, 1992·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·M WashioM Fujishima
Jan 1, 1989·Advances in Experimental Medicine and Biology·W Fried
Jun 1, 1982·Proceedings of the Society for Experimental Biology and Medicine·B A NaughtonA S Gordon
May 1, 1981·The Journal of Clinical Investigation·D MeytesS G Massry
Nov 1, 1995·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·E RitzM Rambausek
Jan 1, 1995·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·T B Drüeke
Jan 1, 1995·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·B Danielson
Jan 1, 1995·American Journal of Nephrology·D I StenverB Nielsen
Aug 7, 1993·Lancet·A ArgilésC M Mion
Feb 1, 1993·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·R M Hakim, N Levin
Feb 15, 1996·The New England Journal of Medicine·O IfuduE A Friedman
Dec 24, 1997·Journal of the American Society of Nephrology : JASN·F MadoreW F Owen
Oct 21, 1999·Journal of Renal Nutrition : the Official Journal of the Council on Renal Nutrition of the National Kidney Foundation·P KhajehdehiB Bastani

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Citations

Sep 17, 2002·Journal of the American College of Surgeons·Christopher R McHenry
Aug 30, 2003·Journal of the American College of Surgeons·Steven A De Jong
Oct 14, 2005·Nephrology·Grahame J Elder
Aug 28, 2009·Seminars in Dialysis·Cyrielle Almeras, Angel Argilés
Nov 12, 2005·European Journal of Clinical Investigation·R Deicher, W H Hörl
May 17, 2018·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Motoko TanakaMasafumi Fukagawa
Jan 30, 2007·Hemodialysis International·Yelena SlininAllan J Collins

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