Abstract
Secondary hyperparathyroidism (2-HPT) has an adverse effect on renal anemia and may cause a hyporesponsiveness to recombinant human erythropoietin (rHuEpo) in patients with chronic renal failure. The early effects of parathyroidectomy (PTx) on renal anemia, erythropoietin production, and nutritional state were examined. Twenty-nine patients under hemodialysis therapy received a PTx for 2-HPT. They were prospectively studied regarding hematological parameters, rHuEpo use, plasma erythropoietin levels, and nutritional condition until 12 months after PTx. The hemoglobin level showed a significant increase from 3 months after PTx (10.2% +/- 1.5% to 11.2% +/- 1.3%; P <0.01), associated with a consistent increase of the reticulocyte count. These changes lasted until 12 months after PTx. The plasma erythropoietin level showed a gradual increase of up to about 5 times the level of the preoperative value, until 12 months after PTx (22.6 +/- 10.1 to 106.3 +/- 112.1 mU/mL; P <0.001). The weekly dose of rHuEpo administration decreased after 3 months. The serum levels of albumin and total protein also significantly and gradually improved until 12 months after PTx. PTx caused a significant early improvement in renal anemia in patients with s...Continue Reading
References
Aug 1, 1979·Archives of Internal Medicine·G L Barbour
Dec 1, 1976·The American Journal of Digestive Diseases·T N ReismanA I Rogers
Jul 1, 1975·The Journal of Clinical Investigation·K A HruskaJ Markham
Jan 1, 1992·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·M WashioM Fujishima
Jan 1, 1992·Nephron·D KampfM Schostak
Jan 1, 1991·Nephron·P UreñaA Kurtz
Jan 1, 1991·Nephron·F StockenhuberP Balcke
Jan 1, 1989·Advances in Experimental Medicine and Biology·W Fried
Nov 1, 1988·Annals of Surgery·H TakagiT Kano
Jun 1, 1982·Proceedings of the Society for Experimental Biology and Medicine·B A NaughtonA S Gordon
May 1, 1981·The Journal of Clinical Investigation·D MeytesS G Massry
Nov 1, 1995·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·E RitzM Rambausek
Jan 1, 1995·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·T B Drüeke
Jan 1, 1995·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·B Danielson
Jan 1, 1995·American Journal of Nephrology·D I StenverB Nielsen
Aug 7, 1993·Lancet·A ArgilésC M Mion
Jan 21, 1993·The New England Journal of Medicine·D S RaoR Mohini
Feb 1, 1993·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·R M Hakim, N Levin
Feb 15, 1996·The New England Journal of Medicine·O IfuduE A Friedman
Dec 24, 1997·Journal of the American Society of Nephrology : JASN·F MadoreW F Owen
Feb 7, 1998·Nephron·M GoicoecheaF Valderrábano
Oct 21, 1999·Journal of Renal Nutrition : the Official Journal of the Council on Renal Nutrition of the National Kidney Foundation·P KhajehdehiB Bastani
Dec 10, 1999·American Journal of Surgery·C YasunagaT Goya
Citations
Sep 17, 2002·Journal of the American College of Surgeons·Christopher R McHenry
Aug 30, 2003·Journal of the American College of Surgeons·Steven A De Jong
Oct 14, 2005·Nephrology·Grahame J Elder
Aug 28, 2009·Seminars in Dialysis·Cyrielle Almeras, Angel Argilés
Dec 2, 2008·Surgery·Joseph A TrunzoScott M Wilhelm
Nov 12, 2005·European Journal of Clinical Investigation·R Deicher, W H Hörl
May 17, 2018·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Motoko TanakaMasafumi Fukagawa
Jan 30, 2007·Hemodialysis International·Yelena SlininAllan J Collins
Sep 10, 2004·Renal Failure·Chun-Liang LinChiu-Ching Huang