PMID: 19145928Jan 17, 2009Paper

Early effects of recanalization of a chronically occluded coronary artery on autonomic nervous system activity

Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego
Ludmiła Daniłowicz-SzymanowiczGrzegorz Raczak

Abstract

Recanalization of a chronically occluded coronary artery results in the improvement of various clinical parameters in patients with coronary artery disease. Increase of parasympathetic activity due to such procedure could be another argument for attempting recanalization. The aim of the study was to evaluate direct effects of recanalization of a chronically occluded coronary artery on the autonomic nervous system activity in patients with single-vessel coronary artery disease. Forty patients aged 57 +/- 10 (36-73 years), scheduled for recanalization of a chronically occluded coronary artery were included into the study. Left ventricular ejection fraction (LVEF), mean heart period (MHP), baroreflex sensitivity (BRS) and short-term heart rate variability indices (SDNN, pNN50, RMSSD, TP, LFnu, HFnu, LF/HF) were analyzed one day before (El) and one day after (E2) the procedure. Statistically significant increase of LVEF in E2 in comparison to E1 (53 +/- 7 and 50 +/- 8%, respectively; p=0.005) and borderline decrease in BRS (4.2 +/- 3.6 and 5.8 +/- 4.6 ms/mm Hg, p=0.06) were found in the studied group. Statistically significant decrease in BRS was found in a subgroup of patients with initial value of BRS > 3 ms/ mm Hg (5.8 +/- 4.3 a...Continue Reading

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