PMID: 16518530Mar 7, 2006Paper

Early effects of simvastatin versus atorvastatin on oxidative stress and proinflammatory cytokines in hyperlipidemic subjects

Angiology
Mary E MarketouPanos E Vardas

Abstract

The authors investigated the time-dependent action of atorvastatin and simvastatin on oxidative stress and cytokine levels immediately after the start of treatment. These factors play a role in endothelial dysfunction. Hyperlipidemic patients (n = 132) were assigned to treatment with 40 mg atorvastatin, 40 mg simvastatin, or placebo. Blood samples were taken before, 2 hours, 24 hours, 7 days, and 3 weeks after the administration of the statin or placebo to evaluate serum concentrations of total peroxides (TP), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha) and soluble intercellular vascular adhesion molecule 1 (sICAM 1). In the atorvastatin group the TP changes were significantly different at 2 hours and 24 hours (p = 0.005), whereas in the simvastatin group there was a gradual, more or less linear decline in TP until 7 days (p = 0.006) and then a plateau. Simvastatin exhibited a faster statistically significant decrease over time in IL-6 and sICAM 1 levels (at 7 days, p = 0.014 and p = 0.001, respectively). TNF-alpha demonstrated a faster linear trend in the simvastatin group, but the significant effect appeared late (p = 0.006). Both simvastatin and atorvastatin exerted early beneficial effects on oxidative str...Continue Reading

References

Jul 1, 1996·Clinical and Experimental Immunology·C WatsonK A Brown
Aug 12, 1998·Atherosclerosis·K P MellwigG Notohamiprodjo
Apr 13, 2001·JAMA : the Journal of the American Medical Association·G G SchwartzUNKNOWN Myocardial Ischemia Reduction with Aggressive Cholesterol Lowering (MIRACL) Study Investigators
Apr 13, 2001·Journal of the American College of Cardiology·S JohnR E Schmieder
Aug 25, 2001·The American Journal of Cardiology·J M Foody, S E Nissen
Dec 18, 2001·Arteriosclerosis, Thrombosis, and Vascular Biology·G K Hansson
Jan 5, 2002·Current Atherosclerosis Reports·Christopher C Case, Christie M Ballantyne
Jul 5, 2002·The New England Journal of Medicine·Antonino BuffonAttilio Maseri
Jan 11, 2003·The American Journal of Cardiology·Haruyo YamashitaHiroyuki Daida
Nov 5, 2003·Current Medical Research and Opinion·Stavroula TsiaraDimitri P Mikhailidis
Jun 10, 2004·Atherosclerosis·Thomas FehrPeter Ammann
Oct 19, 2004·Atherosclerosis·Elia AscerCarlos V Serrano

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Citations

Nov 17, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Christine Y IvashchenkoDouglas G Johns
Sep 13, 2008·Journal of Endocrinological Investigation·E SantiniA Solini
Apr 15, 2014·Archives of Medical Research·Carlos Rodrigo Cámara-LemarroyNancy Esthela Fernández-Garza
Mar 13, 2010·The American Journal of the Medical Sciences·Alptekin YasimYakup Gümüşalan
Sep 17, 2009·Cell Biochemistry and Function·Xiuping ChenYitao Wang
Sep 20, 2012·Biotechnic & Histochemistry : Official Publication of the Biological Stain Commission·R FarahR Khamisy-Farah
May 13, 2010·Biochimica Et Biophysica Acta·Angela Wirth
Sep 22, 2012·The Journal of Thoracic and Cardiovascular Surgery·Nassrene Y ElmadhunFrank W Sellke
Dec 28, 2007·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Rosalia LoPrestiGregorio Caimi
Mar 12, 2015·The Cochrane Database of Systematic Reviews·Stephen P AdamsJames M Wright
Jan 3, 2009·Clinical Science·Hanrui ZhangCuihua Zhang
Oct 8, 2014·Experimental and Therapeutic Medicine·Burak Cem Soner, Ayşe Saide Sahin
Nov 3, 2011·International Journal of Food Sciences and Nutrition·Golaleh AsghariFereidoun Azizi

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