Early endometrial carcinoma: clinicopathology, hormonal aspects, molecular genetics, diagnosis, and treatment

International Journal of Clinical Oncology
Tanri Shiozawa, Ikuo Konishi

Abstract

The number of patients with endometrial carcinoma is markedly increasing in Japan. Therefore, understanding of its biological characteristics and establishment of appropriate treatment are important. In this article, we first describe the clinicopathology of the two types of endometrial carcinoma with their hormonal background and genetic alterations, and then discuss the pathways of early endometrial carcinogenesis. In addition, we also review the diagnostic and therapeutic modalities for early endometrial carcinomas with current controversies, especially regarding postoperative treatment strategies.

References

Jan 1, 1992·Molecular Carcinogenesis·J I RisingerJ Boyd
Feb 1, 1985·Gynecologic Oncology·J V BokhmanA S Vishnevsky
Apr 1, 1985·American Journal of Obstetrics and Gynecology·W T CreasmanD L Clarke-Pearson
May 1, 1995·American Journal of Obstetrics and Gynecology·B KarlssonL Valentin
Apr 1, 1995·Obstetrics and Gynecology·G GitschN F Hacker
Feb 17, 1999·Proceedings of the National Academy of Sciences of the United States of America·K PodsypaninaR Parsons
Apr 15, 1999·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·C D RolitskyT H Niemann
Jun 8, 2000·Journal of the National Cancer Institute·G L MutterC Eng
Jan 10, 2001·International Journal of Cancer. Journal International Du Cancer·H B SalvesenS Das
Feb 13, 2001·British Journal of Cancer·M SaegusaI Okayasu
Feb 17, 2001·The Journal of Pathology·H LagardaJ Prat
Jun 8, 2001·The American Journal of Pathology·G L Mutter
Jun 30, 2001·Human Pathology·X Matias-GuiuJ Prat
Jun 18, 2002·Nature·Helen DaviesP Andrew Futreal
Dec 4, 2002·Virchows Archiv : an International Journal of Pathology·Andrzej SemczukRegine Schneider-Stock
May 7, 2003·Proceedings of the National Academy of Sciences of the United States of America·Paul J GoodfellowDavid G Mutch
Oct 11, 2003·Obstetrics and Gynecology·Walter H GotliebGilad Ben-Baruch
Feb 10, 2004·Gynecologic Oncology·Hitoshi NiikuraNobuo Yaegashi
May 7, 2004·Current Opinion in Obstetrics & Gynecology·Aureli Torné, Luis M Puig-Tintoré
Mar 2, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Janiel M CragunAndrew Berchuck
Mar 8, 2005·Fertility and Sterility·Sangchai Preutthipan, Yongyoth Herabutya
Mar 26, 2005·Cell Transplantation·Yung-Hsiao ChiangYun Wang
Sep 8, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Yu-Zhen FengIkuo Konishi
Jul 3, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Kimio UshijimaToshiharu Kamura

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Citations

Nov 11, 2010·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Huilan ShaHongbo Wang
Jan 7, 2011·Cancer Microenvironment : Official Journal of the International Cancer Microenvironment Society·Ashley S FelixFaina Linkov
May 28, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Israel ZighelboimPaul J Goodfellow
Feb 27, 2009·Future Oncology·Sara A Byron, Pamela M Pollock
Jan 11, 2012·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Piritta HynninenEija Tomas
Jan 15, 2013·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Fanling MengGe Lou
May 22, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Israel ZighelboimDavid G Mutch
Jan 17, 2013·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Yunduo LiuGe Lou
Dec 3, 2008·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Yong-Tark JeonYong-Sang Song
Oct 13, 2009·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Tomasz LesniewiczStanisław Sulkowski
Aug 9, 2019·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Firouzeh HeidariManouchehr Nakhjavani
Dec 10, 2015·International Journal of Oncology·Kentaro NakayamaSatoru Kyo
Dec 14, 2006·Human Molecular Genetics·Kristjana EinarsdóttirSara Wedrén
Oct 27, 2020·Minerva medica·Matteo MorottiStephen Damato

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