Early endothelialization associated with a biolimus A9 bioresorbable polymer stent in a porcine coronary model

Heart and Vessels
Masayuki MoriKenshi Hayashi

Abstract

Although Nobori®, with a bioresorbable polymer and biolimus A9 abluminal coating, has unique characteristics, few data exist regarding endothelialization early after implantation. Fifteen Nobori® and 14 control bare-metal stents (S-stent™) were implanted in 12 pigs. Histopathology of stented segments, inflammation, and intimal fibrin content was evaluated on the 2nd and 14th day after implantation. On the 2nd day, endothelial cells were morphologically and immunohistologically confirmed on the surface of both stents, although some inflammatory cells might be involved. Stent surface endothelialization evaluated with a scanning electron microscope showed partial cellular coverage in both stents. On the 14th day, neointimal thickness and percentage of the neointimal area were significantly lower in Nobori® than in S-stent™ (51.4 ± 4.5 vs. 76.4 ± 23.6 µm, p < 0.05 and 10.8 ± 2.6 vs. 14.1 ± 4.2%, p < 0.01). No significant differences were found in these parameters on the 2nd day (17.3 ± 14.9 vs. 26.7 ± 13.6 µm and 3.7 ± 3.0 vs. 6.7 ± 3.7%), in inflammatory and intimal fibrin content scores. These results demonstrate that endothelialization could occur early after Nobori® implantation with similar inflammatory reaction to bare-metal ...Continue Reading

References

Feb 1, 1992·Journal of the American College of Cardiology·R S SchwartzD R Holmes
Sep 1, 1994·Baillière's Clinical Haematology·J D Pearson
Jan 13, 1999·Circulation·A FarbR Virmani
Jul 18, 2001·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·A J TaylorR Virmani
Feb 3, 2006·The New England Journal of Medicine·Patrick W SerruysAndrew T L Ong
Jul 4, 2006·Journal of the American College of Cardiology·Michael JonerRenu Virmani
Dec 19, 2006·Journal of the American College of Cardiology·Matthias PfistererUNKNOWN BASKET-LATE Investigators
Apr 21, 2012·JACC. Cardiovascular Interventions·Lakshmana K PendyalaJinsheng Li
Oct 23, 2012·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Hitomi HagiwaraJunji Kimura
Feb 5, 2013·Lancet·Evald Høj ChristiansenUNKNOWN Scandinavian Organization for Randomized Trials with Clinical Outcome (SORT OUT) V investigators
May 21, 2013·Journal of the American College of Cardiology·Masahiro NatsuakiUNKNOWN NEXT Investigators
Jan 11, 2014·Heart and Vessels·Takafumi KurosawaHatsue Ishibashi-Ueda
Sep 30, 2014·Circulation Journal : Official Journal of the Japanese Circulation Society·Noritoshi HiranumaKen-Ichi Hirata
Oct 21, 2014·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Gaku NakazawaYuji Ikari
Jun 2, 2015·Circulation Journal : Official Journal of the Japanese Circulation Society·Kensuke NishimiyaHiroaki Shimokawa

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