Early Enhanced Parenteral Nutrition, Hyperglycemia, and Death Among Extremely Low-Birth-Weight Infants

JAMA Pediatrics
Hans Jorgen StensvoldArild E Ronnestad

Abstract

Efforts to optimize early parenteral nutrition (PN) in extremely low-birth-weight (ELBW) infants to promote growth and development may increase hyperglycemia risk. Recent studies have identified an association between early hyperglycemia and adverse outcomes in ELBW infants. To examine the prevalence of early hyperglycemia and clinical outcomes among ELBW infants before (2002-2005) and after (2006-2011) the implementation of an early enhanced PN protocol and to assess the independent effects of early enhanced PN and early hyperglycemia on mortality. Observational cohort study in a level III neonatal intensive care unit. Prospectively collected clinical data in the neonatal intensive care unit's medical database, nutritional information, and blood glucose levels were merged for analysis. All ELBW infants born between January 1, 2002, and December 31, 2011, without lethal malformations and still alive at 12 hours of life were eligible for inclusion in the study. Mortality was the main outcome measure. Severe hyperglycemia was defined as 2 consecutive blood glucose levels exceeding 216 mg/dL at least 3 hours apart. A multivariable logistic regression model was applied to determine the independent effects of early enhanced PN and h...Continue Reading

Citations

Jun 2, 2017·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Kristin CaponeTimothy Sentongo
Feb 27, 2018·Journal of Pediatric Gastroenterology and Nutrition·Anna C TottmanJane M Alsweiler
Feb 2, 2020·NeoReviews·Sara Ramel, Raghavendra Rao
Sep 29, 2020·Frontiers in Neurology·Gianluca TerrinMario De Curtis
Dec 12, 2020·PLoS Medicine·Elsa Kermorvant-DucheminJean-Christophe Rozé
Jan 12, 2021·Advances in Neonatal Care : Official Journal of the National Association of Neonatal Nurses·Sandra S GarnerSarah N Taylor
Aug 1, 2021·Archives of Disease in Childhood. Fetal and Neonatal Edition·Chandra Prakash RathSanjay Patole
Aug 10, 2021·Frontiers in Pediatrics·Kathryn Beardsall

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