Early Enteral Nutrition Reduces Mortality and Improves Other Key Outcomes in Patients With Major Burn Injury: A Meta-Analysis of Randomized Controlled Trials

Critical Care Medicine
Hong PuMatilde J Allingstrup

Abstract

To identify, appraise, and synthesize current evidence to determine whether early enteral nutrition alters patient outcomes from major burn injury. Medline, Embase, and the China National Knowledge Infrastructure were searched. The close out date was May 1, 2018. Early enteral nutrition was defined as a standard formula commenced within 24 hours of injury or admission to ICU or burn unit. Comparators included any form of nutrition support "except" early enteral nutrition. Only randomized controlled trials reporting patient-centered outcomes were eligible for inclusion. The primary outcome was mortality. Gastrointestinal hemorrhage, sepsis, pneumonia, renal failure, and hospital stay were evaluated as secondary outcomes. Nine-hundred fifty-eight full-text articles were retrieved and screened. Seven randomized controlled trials enrolling 527 participants with major burn injury were included. Compared with all other types of nutrition support, early enteral nutrition significantly reduced mortality (odds ratio, 0.36; 95% CI, 0.18-0.72; p = 0.003; I = 0%). Early enteral nutrition also significantly reduced gastrointestinal hemorrhage (odds ratio, 0.21; 95% CI, 0.09-0.51; p = 0.0005; I = 0%), sepsis (odds ratio, 0.23; 95% CI, 0.11-0...Continue Reading

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Citations

Nov 18, 2018·Critical Care Medicine·David Dries
Feb 16, 2019·Critical Care Medicine·Sarah J PetersonCarol A Braunschweig
Oct 24, 2019·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Sérgio Henrique LossLuciana Verçoza Viana
Aug 9, 2020·JPEN. Journal of Parenteral and Enteral Nutrition·Emma Louise SierpLee-Anne S Chapple
Apr 16, 2019·Critical Care Medicine·Gordon S Doig
Apr 16, 2019·Critical Care Medicine·Xia Feng, Baolang Leng
May 7, 2020·Anaesthesia and Intensive Care·Francois Stapelberg
Mar 14, 2021·Brazilian Journal of Anesthesiology·Matthaios Papadimitriou-OlivgerisFotini Fligou
Nov 15, 2020·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Berner Andrée Sandoval-RamírezRosa Solà
Apr 23, 2021·Journal of Burn Care & Research : Official Publication of the American Burn Association·Joachim N MeuliWassim Raffoul

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