PMID: 8580709Oct 1, 1995Paper

Early events in neurotrophin signalling via Trk and p75 receptors

Current Opinion in Neurobiology
L A Greene, D R Kaplan

Abstract

Biological responses to neurotrophins appear to be mediated by multiple signalling pathways. These emanate from, and are regulated by, the contributions of both Trk and p75 receptors. Early events in Trk signalling are becoming more clearly defined and point to cooperate interaction of both Ras-dependent and Ras-independent pathways. Work over the past year has clarified the steps by which Trk receptor occupation leads to Ras activation and has highlighted the required roles of Ras and extracellular signal regulated kinases in certain neurotrophin responses, including neurite outgrowth. Pharmacologic and mutagenesis studies have additionally supported the importance of the phosphatidylinositol-3' kinase and SNT protein pathways in neurotrophin signalling. Although many findings point to clear involvement for p75 in neurotrophin signalling, the molecular mechanisms by which these occur are just beginning to be identified. Recent studies indicate that p75 dramatically influences Trk activity and ligand interactions, and may mediate signals through the ceramide second-messenger pathway.

References

Oct 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·S Raffioni, R A Bradshaw
Oct 1, 1990·Molecular and Cellular Biology·J SzeberényiG M Cooper
Oct 1, 1986·Journal of Cellular Physiology·I GuerreroD E Burstein
Oct 1, 1994·Current Opinion in Neurobiology·R Heumann
Mar 10, 1995·Science·S Nagata, P Golstein
Apr 1, 1995·Molecular and Cellular Neurosciences·M V Chao
Jan 1, 1995·Annual Review of Neuroscience·M Bothwell
May 19, 1995·Cell·J L Cleveland, J N Ihle
Feb 3, 1995·The Journal of Biological Chemistry·D E WolfA H Ross
Nov 1, 1994·Journal of Neurobiology·M V Chao
Nov 1, 1994·Journal of Neurobiology·D R Kaplan, R M Stephens
Jan 1, 1994·Annual Review of Cell Biology·P van der GeerR A Lindberg
May 1, 1994·Molecular Biology of the Cell·D O ClaryL F Reichardt
Jul 5, 1994·Proceedings of the National Academy of Sciences of the United States of America·G L Barrett, P F Bartlett
Aug 18, 1994·Nature·P Rodriguez-VicianaJ Downward
Sep 2, 1994·Science·C A Lange-Carter, G L Johnson
Mar 29, 1994·Proceedings of the National Academy of Sciences of the United States of America·E S AntonW D Matthew

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Citations

Nov 19, 1997·Journal of Neuroscience Research·H Jiang, G Guroff
Jan 7, 1998·Journal of Neuroscience Research·H H AlthausR Heumann
Sep 1, 1996·Journal of Cellular Biochemistry·D RasoulyP I Lelkes
Jan 9, 2001·Journal of Cellular Physiology·C MirandaE Van Obberghen
May 7, 2002·Journal of Neuroscience Research·Vidya Mamidipudi, Marie W Wooten
Sep 5, 2002·Journal of Neuroscience Research·Hisanori ItoShoei Furukawa
Feb 8, 2000·Analytical Biochemistry·T S AngelesS X Yang
Apr 16, 2004·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Ben DavidsonCarlos Bedrossian
Nov 20, 1998·Journal of Neuroscience Methods·J G Bilsland, S J Harper
Oct 6, 2000·Brain Research. Developmental Brain Research·C Labelle, N Leclerc
Jul 1, 1997·Trends in Neurosciences·D E Bredesen, S Rabizadeh
Jan 1, 1997·Trends in Neurosciences·A Tolkovsky
Nov 26, 1998·Trends in Neurosciences·E Cattaneo, P G Pelicci
Jul 11, 2002·Brain Research. Molecular Brain Research·Harold J SheedloRouel S Roque
Mar 26, 2003·Brain Research. Molecular Brain Research·Sara TaylorRouel S Roque
Apr 29, 1998·Brain Research. Molecular Brain Research·K TanabeH Kiyama
Apr 10, 2003·Progress in Neurobiology·Joel H Benington, Marcos G Frank
Feb 13, 1999·Progress in Neurobiology·M J Millan
Oct 16, 2001·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·T LumG Heinrich
Aug 15, 1998·Journal of Chemical Neuroanatomy·C E Van der Zee, T Hagg
Apr 1, 1997·Current Opinion in Cell Biology·D R Kaplan, F D Miller

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