Early Evidence of the Effectiveness of the Human Papillomavirus Vaccination Program Against Anogenital Warts in Manitoba, Canada: A Registry Cohort Study

Sexually Transmitted Diseases
Karla WillowsSalaheddin M Mahmud

Abstract

We assessed the effectiveness of the quadrivalent human papillomavirus vaccine (qHPV) vaccination program in Manitoba, Canada, in reducing incident anogenital warts (AGWs) and to what extent effectiveness depends on age at vaccination and number of doses. Female participants 9 years or older who received the qHPV in Manitoba between September 2006 and March 2013 (n = 31,464) through the publicly funded school-based program and a high-risk catch-up program were included. They were matched on age and area of residence to unvaccinated female participants. Information on incident AGWs was obtained from provincial administrative databases using validated algorithms. Using stratified Cox regression models, we estimate hazard ratios (HRs) for the association between qHPV and AGWs. For female participants vaccinated at age 18 years or younger, receipt of qHPV was associated with a 40% reduction in AGW risk (HR, 0.6; 95% confidence interval [CI], 0.4-0.8). Further adjustment for socioeconomic and medical history did not alter this estimate. For women vaccinated at age 19 years or older, we saw an increase in AGW incidence, especially among those who were sexually active (HR, 2.8; 95% CI, 2.1-3.7). Among female participants vaccinated at...Continue Reading

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Citations

Jan 18, 2019·International Journal of Cancer. Journal International Du Cancer·Christiaan H RigholtSalaheddin M Mahmud
Dec 1, 2019·The Journal of Infectious Diseases·Lauri E MarkowitzElizabeth R Unger
Oct 14, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Louise BaandrupSusanne K Kjaer

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